Description

4-Chloro-5-(Trifluoromethyl)Pyrimidin-2-Amine CAS NO 1201657-24-0 is a high-value, halogenated pyrimidine derivative serving as a critical building block in advanced organic synthesis. Its molecular structure, featuring both chloro and trifluoromethyl substituents, makes it an essential intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for antiviral, anticancer, and kinase inhibitor drug candidates.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Material Science Research: Serves as a monomer or functionalizing agent in the development of specialty polymers, liquid crystals, and electronic materials.
• Chemical Biology & Proteomics: Employed as a molecular scaffold or labeling reagent in the design of chemical probes and enzyme inhibitors for target validation studies.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	4-Chloro-5-(Trifluoromethyl)Pyrimidin-2-Amine
CAS No.	1201657-24-0
Molecular Formula	C5H3ClF3N3
Molecular Weight	197.55 g/mol
Synonyms	2-Amino-4-chloro-5-(trifluoromethyl)pyrimidine; 4-Chloro-5-trifluoromethyl-2-pyrimidinamine; 5-(Trifluoromethyl)-4-chloropyrimidin-2-amine; 4-Chloro-5-(trifluoromethyl)-2-pyrimidinamine; 2-Pyrimidinamine, 4-chloro-5-(trifluoromethyl)-; 1201657-24-0; 4-Chloro-5-trifluoromethylpyrimidin-2-ylamine
EINECS	Contact for details

Quality Control

Every batch of 4-Chloro-5-(Trifluoromethyl)Pyrimidin-2-Amine is produced and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the exacting standards required for research and scale-up activities. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and impurity profiles as determined by advanced chromatographic and spectroscopic methods.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong acids, strong bases, and strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.