Description

Fmoc-α-Me-D-Gly(Pentynyl)-Oh is a specialized, non-proteinogenic amino acid derivative designed for advanced peptide synthesis. This compound matters for its role as a key building block in Solid-Phase Peptide Synthesis (SPPS), enabling the precise incorporation of a unique, alkyne-functionalized side chain for subsequent bioorthogonal conjugation, such as click chemistry. Pharmaceutical researchers and peptide manufacturers need it for developing novel peptide-drug conjugates (PDCs), constrained peptides, and other bioactive molecules where precise structural modification is critical.

Application

• Solid-Phase Peptide Synthesis (SPPS): A critical protected amino acid building block for the automated synthesis of complex peptides.
• Peptide-Drug Conjugate (PDC) Development: Enables site-specific attachment of cytotoxic drugs, fluorophores, or other payloads via its alkyne handle for click chemistry reactions.
• Chemical Biology & Proteomics: Used to create peptide probes for studying protein-protein interactions, enzyme activity, and cellular localization.
• Constrained Peptide & Macrocycle Synthesis: Facilitates the introduction of structural constraints or cyclization points to enhance peptide stability and biological activity.
• Material Science & Bioconjugation: Serves as a linker for attaching peptides to surfaces, nanoparticles, or polymers to create functional biomaterials.
• Antibody-Drug Conjugate (ADC) Research: Employed in the synthesis of peptide linkers that connect antibodies to therapeutic agents.

Basic Information

Product Name	Fmoc-α-Me-D-Gly(Pentynyl)-Oh
CAS No.	1198791-56-8
Molecular Formula	C₂₅H₂₇NO₄
Molecular Weight	405.49 g/mol
Synonyms	Fmoc-α-Me-D-Gly(Pentynyl)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-α-methyl-D-propargylglycine; Fmoc-D-α-methyl-propargylglycine; Fmoc-D-α-Me-Pra-OH (common abbreviation); (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2-methylpent-4-ynoic acid; Fmoc-α-methyl-D-2-amino-pent-4-ynoic acid; Fmoc-D-α-Me-Pentynyl-Gly-OH
EINECS	Contact for details

Quality Control

Our Fmoc-α-Me-D-Gly(Pentynyl)-Oh is manufactured under strict quality systems to ensure the high purity and consistency required for sensitive pharmaceutical research and peptide synthesis. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, chiral integrity, and impurity profiles. We adhere to relevant industry standards and can provide material suitable for use under cGMP guidelines for advanced therapeutic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥97.0%
Chiral Purity (HPLC)	≥99.0% D-isomer
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.