Description

Fmoc-D-Lys(N3)-Oh is a specialized, non-natural amino acid derivative designed for advanced peptide synthesis and bioconjugation. This compound is critical for researchers and manufacturers requiring precise, site-specific modifications, particularly through bioorthogonal click chemistry. It is essential for professionals in pharmaceutical R&D, proteomics, and the development of novel biotherapeutics and diagnostic agents.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key building block for the controlled incorporation of azide-functionalized lysine residues into peptide chains using Fmoc-chemistry protocols.
• Bioconjugation and Linker Chemistry: Enables site-specific labeling of peptides, proteins, and antibodies via copper-catalyzed or strain-promoted azide-alkyne cycloaddition (CuAAC/SPAAC) click reactions.
• Drug Discovery & Development: Used to create peptide-drug conjugates (PDCs) and other advanced therapeutic candidates with tailored pharmacokinetic properties.
• Chemical Biology & Proteomics: Facilitates the study of protein-protein interactions, cellular localization, and post-translational modifications through bioorthogonal tagging strategies.
• Material Science & Surface Functionalization: Serves as a precursor for modifying surfaces and polymers with bioactive peptides for sensor development and biomaterials.

Basic Information

Product Name	Fmoc-D-Lys(N3)-Oh
CAS No.	1198791-53-5
Molecular Formula	C22H25N5O4
Molecular Weight	423.47 g/mol
Synonyms	Fmoc-D-Lys(N3)-OH; Nα-Fmoc-Nε-azido-D-lysine; Fmoc-D-Lysine(N3)-OH; (2R)-6-Azido-2-[(9H-fluoren-9-ylmethoxy)carbonylamino]hexanoic acid; Fmoc-D-Lys(N3); N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-Nε-azido-D-lysine; Azido-D-lysine Fmoc derivative; Fmoc-D-Lys(Azide)-OH
EINECS	Contact for details

Quality Control

Our Fmoc-D-Lys(N3)-Oh is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency, suitable for sensitive research and development applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable, and specifications can be aligned with client requirements for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. This product is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.