Description

2-(2-Chloro-6-Morpholino-9H-Purin-8-Yl)Propan-2-Ol is a high-purity, advanced pharmaceutical intermediate belonging to the purine class of heterocyclic compounds. This compound is of significant commercial importance due to its role as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting kinase inhibition. It is primarily required by research institutions and pharmaceutical manufacturers engaged in the development and production of novel therapeutic agents, including potential treatments for oncology and inflammatory diseases.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of targeted kinase inhibitors and other specialized drug candidates.
• Biochemical Research: Used as a reference standard or a starting material in medicinal chemistry research for structure-activity relationship (SAR) studies.
• Process Development: Employed in the scale-up and optimization of synthetic routes for new chemical entities (NCEs) under Good Manufacturing Practice (GMP) conditions.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of clinical trial materials and commercial APIs.

Basic Information

Product Name	2-(2-Chloro-6-Morpholino-9H-Purin-8-Yl)Propan-2-Ol
CAS No.	1198171-62-8
Molecular Formula	C12H16ClN5O2
Molecular Weight	297.74 g/mol
Synonyms	2-(2-Chloro-6-morpholin-4-yl-9H-purin-8-yl)propan-2-ol; 2-(2-Chloro-6-morpholino-9H-purin-8-yl)-2-propanol; 8-(2-Hydroxy-2-propanyl)-2-chloro-6-morpholino-9H-purine; 2-Chloro-6-morpholino-8-(2-hydroxypropan-2-yl)-9H-purine; 2-Chloro-6-morpholin-4-yl-8-(2-hydroxypropan-2-yl)-9H-purine; 1198171-62-8; 2-(2-Chloro-6-morpholinopurin-8-yl)propan-2-ol
EINECS	Contact for details

Quality Control

Our 2-(2-Chloro-6-Morpholino-9H-Purin-8-Yl)Propan-2-Ol is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for demanding pharmaceutical applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles as determined by advanced analytical techniques. We adhere to ICH guidelines for stability and impurity characterization to support our clients' regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). The compound is light-sensitive (store away from light) and may be hygroscopic (moisture-sensitive); therefore, containers should be kept sealed under an inert atmosphere if specified.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Purity (HPLC)	≥ 98.5%
Single Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 1.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.