Description

3-Quinolinecarboxylic Acid, 1-Cyclopropyl-6-Fluoro-1,4-Dihydro-7-[4-(2-Hydroxyethyl)-1-Piperazinyl]-4-Oxo-, Hydrochloride CAS NO 1197238-80-4 is a high-purity, non-GMP active pharmaceutical intermediate (API) with a complex heterocyclic structure. This compound is a critical synthetic precursor in the development of advanced fluoroquinolone antibiotics, offering significant value for research and pharmaceutical manufacturing. It is primarily required by pharmaceutical R&D laboratories, contract manufacturing organizations (CMOs), and fine chemical suppliers serving the global antimicrobial sector.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel broad-spectrum fluoroquinolone antibiotic candidates.
• Antimicrobial Research: Used in medicinal chemistry programs to develop new antibacterial agents with improved potency and safety profiles.
• Process Chemistry & Scale-Up: Serves as a critical starting material for process optimization and pilot-scale production of antibiotic APIs.
• Reference Standard: Employed as an analytical standard for quality control and method development in pharmaceutical analysis.
• Custom Synthesis: Basis for the preparation of structurally related analogs for structure-activity relationship (SAR) studies.

Basic Information

Item	Details
Product Name	3-Quinolinecarboxylic Acid, 1-Cyclopropyl-6-Fluoro-1,4-Dihydro-7-[4-(2-Hydroxyethyl)-1-Piperazinyl]-4-Oxo-, Hydrochloride
CAS No.	1197238-80-4
Molecular Formula	C19H23FN4O4 · HCl
Molecular Weight	426.87 g/mol (Free base: 390.41 g/mol)
Synonyms	1-Cyclopropyl-6-fluoro-1,4-dihydro-7-[4-(2-hydroxyethyl)piperazin-1-yl]-4-oxoquinoline-3-carboxylic acid hydrochloride; 7-[4-(2-Hydroxyethyl)piperazin-1-yl]-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid hydrochloride; Fluoroquinolone Intermediate Hydrochloride; WCK 771 Intermediate (Hydrochloride Salt); Levonadifloxacin Alalevonadifloxacin Intermediate; Benapenem Intermediate (related synthon); ABT-492 Intermediate (Hydrochloride form)
EINECS	Contact for details

Quality Control

Our 3-Quinolinecarboxylic Acid derivative is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals, to ensure it meets the stringent requirements for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed and stored in a dark place to maintain stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.