Description

2-(Difluoromethoxy)-3-Methylbenzaldehyde is a specialized aromatic aldehyde building block featuring a difluoromethoxy substituent, which imparts unique electronic and metabolic stability properties. This compound is valued for its role as a critical intermediate in the synthesis of advanced pharmaceutical and agrochemical active ingredients. It is primarily sought by R&D chemists and process development teams in the life sciences sector for creating novel molecules with enhanced efficacy and patent life.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring fluorinated motifs for improved bioavailability and target binding.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the difluoromethoxy group can enhance lipophilicity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated organic electronic materials for displays and lighting applications.
• Organic Synthesis Building Block: Employed in cross-coupling reactions, such as Suzuki or Heck reactions, and reductive amination to construct complex molecular architectures in medicinal chemistry.
• Fluorine Chemistry Research: An important reagent for academic and industrial research exploring the effects of fluorine and fluorinated alkoxy groups on chemical reactivity and physical properties.

Basic Information

Product Name	2-(Difluoromethoxy)-3-Methylbenzaldehyde
CAS No.	1197237-23-2
Molecular Formula	C9H8F2O2
Molecular Weight	186.16 g/mol
Synonyms	3-Methyl-2-(difluoromethoxy)benzaldehyde; 2-(Difluoromethoxy)-3-methylbenzaldehyde; Benzaldehyde, 2-(difluoromethoxy)-3-methyl-; 3-Methyl-2-difluoromethoxybenzaldehyde; o-(Difluoromethoxy)-m-tolualdehyde
EINECS	Contact for details

Quality Control

Our 2-(Difluoromethoxy)-3-Methylbenzaldehyde is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) with detailed specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.