Description

Fmoc-D-His(1-Me)-OH is a protected, non-natural amino acid derivative specifically designed for solid-phase peptide synthesis (SPPS). This compound is critical for researchers and manufacturers requiring precise control over peptide sequence and structure, particularly for introducing modified histidine residues. It is essential for the development of novel therapeutic peptides, diagnostic agents, and biochemical tools in pharmaceutical R&D and biotechnology. The product is supplied under stringent quality control to ensure optimal performance in automated synthesis platforms.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key building block for the incorporation of methylated D-histidine into custom peptide sequences.
• Pharmaceutical Research: Synthesis of peptide-based drug candidates, including hormone analogs, enzyme inhibitors, and targeted therapeutics.
• Bioconjugation & Probe Development: Creating labeled peptides for diagnostic assays, imaging, and studying protein-protein interactions.
• Structure-Activity Relationship (SAR) Studies: Investigating the effect of histidine methylation and D-configuration on peptide bioactivity and stability.
• Combinatorial Chemistry Libraries: Generation of diverse peptide libraries for high-throughput screening in drug discovery.
• Academic & Industrial R&D: Fundamental research in biochemistry, medicinal chemistry, and molecular biology.

Basic Information

Product Name	Fmoc-D-His(1-Me)-OH
CAS No.	1197025-85-6
Molecular Formula	C₂₂H₂₃N₃O₅
Molecular Weight	409.44 g/mol
Synonyms	Fmoc-D-1-methylhistidine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-1-methyl-D-histidine; (2R)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-(1-methyl-1H-imidazol-4-yl)propanoic acid; Fmoc-D-1-Me-His-OH; Fmoc-D-N(τ)-methylhistidine; Fmoc-1-methyl-D-histidine; N-α-Fmoc-1-methyl-D-histidine; Fmoc-D-His(1-Me)-OH CAS NO 1197025-85-6
EINECS	Contact for details

Quality Control

Our Fmoc-D-His(1-Me)-OH is manufactured under controlled conditions to meet the exacting standards of peptide synthesis. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral analysis to confirm stereochemical integrity. Certificates of Analysis (COA) with detailed chromatographic data are provided to ensure traceability and batch-to-batch consistency for your critical research and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to reach ambient temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% D-isomer
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.