Description

Fmoc-Phe-Thr(Psi-Me,Me Pro)-Oh CAS NO 1196703-48-6 is a specialized, high-purity pseudoproline-containing dipeptide building block used in advanced solid-phase peptide synthesis (SPPS). This compound is engineered to address critical challenges in peptide assembly, such as difficult sequences and aspartimide formation, by introducing a backbone modification that promotes favorable chain conformations. It is an essential raw material for research institutions and pharmaceutical companies developing complex therapeutic peptides, peptidomimetics, and bioactive compounds.

Application

• Solid-Phase Peptide Synthesis (SPPS): A critical building block for the efficient and high-yield synthesis of complex and long-chain peptides, particularly those prone to aggregation or side reactions.
• Therapeutic Peptide Development: Used in the research and production of peptide-based pharmaceuticals targeting metabolic disorders, oncology, and infectious diseases.
• Peptidomimetic Design: Serves as a key intermediate for creating stable peptide analogs with enhanced bioavailability and metabolic stability.
• Bioconjugation and Labeling: Provides a chemically orthogonal handle (Fmoc group) for the site-specific attachment of probes, tags, or drug payloads.
• Academic and Industrial R&D: Essential for fundamental research in peptide chemistry, structure-activity relationship (SAR) studies, and novel methodology development.
• Combinatorial Chemistry Libraries: Used to generate diverse libraries of peptide-like compounds for high-throughput screening in drug discovery.

Basic Information

Product Name	Fmoc-Phe-Thr(Psi-Me,Me Pro)-Oh
CAS No.	1196703-48-6
Molecular Formula	C34H37N3O7
Molecular Weight	599.68 g/mol
Synonyms	Fmoc-L-Phenylalanyl-L-threonyl-N-(2,2-dimethyl-1,3-dioxolan-4-ylmethyl)-L-prolinamide; Fmoc-Phe-Thr(ψMe,Mepro)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-phenylalanyl-N-[(2S,3R)-3-hydroxy-1-[[(2S)-1-[(2,2-dimethyl-1,3-dioxolan-4-yl)methyl]-5-oxopyrrolidin-2-yl]amino]-1-oxobutan-2-yl]-L-phenylalaninamide; Fmoc-Phenylalanine-Threonine(Pseudoproline) derivative; Pseudoproline dipeptide Fmoc-Phe-Thr(ψMe,Mepro)-OH
EINECS	Contact for details

Quality Control

Our Fmoc-Phe-Thr(Psi-Me,Me Pro)-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, critical for sensitive peptide synthesis applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and Mass Spectrometry. A detailed Certificate of Analysis (COA) documenting all specifications is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Assay	≥ 97.0%
Water Content (KF)	≤ 1.0%
Optical Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.