Description

4-(Aminomethyl)-3-(Trifluoromethyl)Aniline Hcl is a high-purity, halogenated aniline derivative of significant interest in advanced organic synthesis. This compound serves as a critical multifunctional building block, offering both a primary amine and a benzylamine group for diverse coupling reactions. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for constructing complex molecular architectures. The presence of the trifluoromethyl group imparts desirable properties such as enhanced metabolic stability and lipophilicity to final target molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and inflammation.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the trifluoromethyl group can improve biological activity and environmental persistence.
• Ligand & Catalyst Development: Serves as a versatile scaffold for creating chelating ligands and organocatalysts used in asymmetric synthesis and metal-catalyzed cross-coupling reactions.
• Material Science Monomer: Employed in the research of specialty polymers and advanced materials, such as polyimides or liquid crystals, where its aromatic and amine functionalities are valuable.
• Fluorine Chemistry Research: An important reagent for studying structure-activity relationships (SAR) and the effects of fluorine substitution in medicinal and materials chemistry.
• Peptide Mimetics & Conjugates: The aminomethyl group allows for incorporation into peptide backbones or for creating antibody-drug conjugates (ADCs) and other bioconjugates.

Basic Information

Product Name	4-(Aminomethyl)-3-(Trifluoromethyl)Aniline Hydrochloride
CAS No.	1196702-81-4
Molecular Formula	C9H10ClF3N2
Molecular Weight	238.64 g/mol
Synonyms	4-(Aminomethyl)-3-(trifluoromethyl)benzenamine hydrochloride; 3-(Trifluoromethyl)-4-(aminomethyl)aniline HCl; 4-(Aminomethyl)-3-(trifluoromethyl)phenylamine hydrochloride; 1-Amino-4-(aminomethyl)-2-(trifluoromethyl)benzene hydrochloride; Benzenamine, 4-(aminomethyl)-3-(trifluoromethyl)-, hydrochloride; 4-(Aminomethyl)-α,α,α-trifluoro-m-toluidine hydrochloride
EINECS	Contact for details

Quality Control

Our production of 4-(Aminomethyl)-3-(Trifluoromethyl)Aniline Hcl adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and KF titration for moisture content. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications. We support compliance with REACH and other global regulatory frameworks as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.