Description

4-(Aminomethyl)-2-(Trifluoromethyl)Aniline Hydrochloride is a high-purity, functionalized aniline derivative of significant interest in advanced organic synthesis. Its bifunctional nature, featuring both a primary aromatic amine and a primary benzylic amine, makes it a versatile and valuable building block for constructing complex molecular architectures. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors. It serves as a critical intermediate for the development of novel active ingredients, particularly those requiring the incorporation of a trifluoromethyl group for enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially for central nervous system (CNS) agents, kinase inhibitors, and anti-infectives.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the trifluoromethyl group improves efficacy and environmental profile.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized chelating ligands and organocatalysts used in asymmetric synthesis.
• Polymer and Material Science: Employed in the synthesis of specialty polymers, dyes, and advanced materials requiring aromatic amine functionality.
• Chemical Research (CRO/CMO): A valuable building block for contract research and manufacturing organizations engaged in custom synthesis and library development for clients.

Basic Information

Product Name	4-(Aminomethyl)-2-(Trifluoromethyl)Aniline Hydrochloride
CAS No.	1196702-79-0
Molecular Formula	C9H10ClF3N2
Molecular Weight	238.64 g/mol
Synonyms	2-(Trifluoromethyl)-1,4-benzenediamine, 4-(aminomethyl) hydrochloride; 4-(Aminomethyl)-2-(trifluoromethyl)benzenamine hydrochloride; 2-(Trifluoromethyl)-4-(aminomethyl)aniline hydrochloride; 4-(Aminomethyl)-α,α,α-trifluoro-o-toluidine hydrochloride; 1,4-Benzenediamine, 2-(trifluoromethyl)-, 4-(aminomethyl)-, hydrochloride; 4-(Aminomethyl)-2-trifluoromethylaniline HCl
EINECS	Contact for details

Quality Control

Our 4-(Aminomethyl)-2-(Trifluoromethyl)Aniline Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for moisture content, to ensure it meets the high standards required for research and scale-up applications. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and consistent quality.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.