Description

3,3-Difluoro-2,3-dihydro-1H-inden-1-amine is a high-purity, fluorinated indane derivative of significant interest in advanced organic synthesis. This compound serves as a critical chiral building block and intermediate for the development of novel active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily utilized by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors seeking to incorporate unique fluorinated motifs into their molecular architectures.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of complex drug candidates, particularly those targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Research: Used in the development of new-generation herbicides, fungicides, and insecticides, where the difluoro group can enhance biological activity and environmental stability.
• Ligand & Catalyst Development: Employed in the creation of novel chiral ligands and organocatalysts for asymmetric synthesis applications.
• Material Science: Acts as a monomer or functional additive in the synthesis of specialty polymers and advanced organic electronic materials.
• Chemical Biology Probe: Utilized as a scaffold for designing molecular probes to study enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring fluorinated indane chemistry.

Basic Information

Product Name	3,3-Difluoro-2,3-dihydro-1H-inden-1-amine
CAS No.	1196156-50-9
Molecular Formula	C9H9F2N
Molecular Weight	169.17 g/mol
Synonyms	1-Amino-3,3-difluoroindane; 3,3-Difluoroindan-1-amine; 3,3-Difluoro-2,3-dihydro-1H-inden-1-amine; 1H-Inden-1-amine, 3,3-difluoro-2,3-dihydro-; (1-Amino-3,3-difluoro-2,3-dihydro-1H-inden-1-yl); 3,3-Difluoro-1-indanamine; 1196156-50-9
EINECS	Contact for details

Quality Control

Our 3,3-Difluoro-2,3-dihydro-1H-inden-1-amine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring GMP-grade intermediates and materials for regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be moisture-sensitive; keep the container tightly sealed under an inert atmosphere for long-term storage. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (Typical)
Water Content (KF)	≤ 0.5% w/w
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.