Description

C-[4-(2,2,2-Trifluoro-Ethoxy)-Pyrimidin-2-Yl]-Methylamine Hydrochloride is a high-purity, organofluorine building block of significant interest in advanced chemical synthesis. This compound matters for its role as a key intermediate in the development of novel active pharmaceutical ingredients (APIs), particularly those targeting central nervous system and metabolic disorders. Pharmaceutical R&D teams and fine chemical manufacturers need it to incorporate the unique physicochemical properties of the trifluoroethoxy and pyrimidine motifs into new molecular entities.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, especially in neurological and metabolic disease research.
• Agrochemical Research: Used in developing advanced pesticides and herbicides, where the fluorine moiety enhances biological activity and environmental stability.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science: Incorporated into the synthesis of specialty polymers and advanced organic electronic materials.
• Bioconjugation & Probe Synthesis: Utilized in medicinal chemistry for creating labeled compounds and biochemical probes for diagnostic applications.
• Academic & Contract Research: Essential for exploratory organic synthesis in university and CRO (Contract Research Organization) laboratories.

Basic Information

Item	Details
Product Name	C-[4-(2,2,2-Trifluoro-Ethoxy)-Pyrimidin-2-Yl]-Methylamine Hydrochloride
CAS No.	1196154-15-0
Molecular Formula	C8H9ClF3N3O
Molecular Weight	255.62 g/mol
Synonyms	1-[4-(2,2,2-Trifluoroethoxy)pyrimidin-2-yl]methanamine hydrochloride; 2-(Aminomethyl)-4-(2,2,2-trifluoroethoxy)pyrimidine hydrochloride; (4-(2,2,2-Trifluoroethoxy)pyrimidin-2-yl)methanamine hydrochloride; C-[4-(2,2,2-Trifluoroethoxy)-2-pyrimidinyl]methylamine hydrochloride; 1196154-15-0; 4-(2,2,2-Trifluoroethoxy)-2-pyrimidinemethanamine hydrochloride
EINECS	Contact for details

Quality Control

Our C-[4-(2,2,2-Trifluoro-Ethoxy)-Pyrimidin-2-Yl]-Methylamine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.