Description

2-Ethynyl-4-Methylpyrimidine is a specialized pyrimidine derivative featuring an ethynyl functional group, making it a valuable alkyne-containing building block for advanced organic synthesis. This compound is critical for researchers and manufacturers developing novel pharmaceuticals, agrochemicals, and functional materials. It is primarily utilized in medicinal chemistry for the construction of targeted molecular libraries and in material science for creating conjugated systems.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and plant growth regulators that require a pyrimidine core structure.
• Material Science: Serves as a precursor for organic electronic materials, including organic light-emitting diodes (OLEDs) and semiconductors, due to its conjugated ethynyl group.
• Chemical Biology & Proteomics: Employed in click chemistry applications, such as Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC), for bioconjugation and probe development.
• Academic & Industrial R&D: A versatile building block for constructing complex heterocyclic compounds in discovery chemistry and process development.

Basic Information

Product Name	2-Ethynyl-4-Methylpyrimidine
CAS No.	1196153-62-4
Molecular Formula	C7H6N2
Molecular Weight	118.14 g/mol
Synonyms	4-Methyl-2-ethynylpyrimidine; 2-Ethynyl-4-methyl-pyrimidine; 2-(Ethynyl)-4-methylpyrimidine; 4-Methyl-2-pyrimidinylethyne
EINECS	Contact for details

Quality Control

Our 2-Ethynyl-4-Methylpyrimidine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications for research and commercial use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere such as nitrogen or argon for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.