Description

Pyrimidine, 5-Ethynyl-2-Methyl- is a high-purity, functionalized pyrimidine derivative characterized by its ethynyl and methyl substituents, offering a versatile chemical handle for advanced synthesis. This compound is a critical pharmaceutical intermediate and building block in medicinal chemistry, enabling the construction of complex molecular architectures. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, agrochemical, and material science sectors for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of nucleoside analogs, kinase inhibitors, and other targeted therapeutic agents.
• Medicinal Chemistry Research: Used in hit-to-lead optimization and structure-activity relationship (SAR) studies due to its modifiable ethynyl group.
• Agrochemical Development: Serves as a precursor for creating novel herbicides, fungicides, and plant growth regulators.
• Material Science: Component in the synthesis of organic semiconductors, ligands for metal-organic frameworks (MOFs), and advanced polymers.
• Chemical Biology: Employed in bioconjugation and probe development via click chemistry reactions facilitated by the alkyne moiety.
• Academic & Industrial R&D: Fundamental reagent for exploring new synthetic methodologies and heterocyclic chemistry.

Basic Information

Product Name	Pyrimidine, 5-Ethynyl-2-Methyl-
CAS No.	1196153-50-0
Molecular Formula	C7H6N2
Molecular Weight	118.14 g/mol
Synonyms	5-Ethynyl-2-methylpyrimidine; 2-Methyl-5-ethynylpyrimidine; 5-Ethynyl-2-methyl-1,3-diazine; 2-Methylpyrimidin-5-ylacetylene; 5-Ethynyl-2-methyl-1,3-diazabenzene
EINECS	Contact for details

Quality Control

Our Pyrimidine, 5-Ethynyl-2-Methyl- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, confirming compliance with agreed specifications. Our quality commitment supports applications in regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.