Description

n-Fmoc-2-Fluoro-L-Tyrosine is a fluorinated, Fmoc-protected derivative of the amino acid L-tyrosine, designed for use in solid-phase peptide synthesis (SPPS). This compound is critical for introducing a site-specific, fluorine-labeled tyrosine residue into peptide chains, enabling advanced research in medicinal chemistry and biochemistry. It is primarily utilized by pharmaceutical R&D teams, peptide synthesis service providers, and academic researchers focused on developing novel therapeutics, PET imaging probes, and studying protein structure-function relationships.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key building block for the controlled incorporation of fluorinated tyrosine analogs into custom peptide sequences.
• Medicinal Chemistry & Drug Discovery: For the synthesis of peptide-based drug candidates where fluorine substitution is used to modulate bioavailability, metabolic stability, and receptor binding affinity.
• Positron Emission Tomography (PET) Tracer Development: Serves as a precursor for synthesizing 18F-labeled peptides used as molecular imaging agents.
• Biochemical Research: Enables the study of enzyme mechanisms, protein-protein interactions, and phosphorylation pathways using fluorine as a subtle structural probe.
• Pharmaceutical Intermediate: Used in the multi-step synthesis of complex active pharmaceutical ingredients (APIs) containing modified tyrosine residues.

Basic Information

Product Name	n-Fmoc-2-Fluoro-L-Tyrosine
CAS No.	1196146-72-1
Molecular Formula	C24H20FNO5
Molecular Weight	421.42 g/mol
Synonyms	Fmoc-2-F-Tyr-OH; Fmoc-2-Fluoro-L-tyrosine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-2-fluoro-L-tyrosine; (2S)-2-[(9H-Fluoren-9-ylmethoxy)formamido]-3-(4-hydroxy-3-fluorophenyl)propanoic acid; 2-Fluoro-L-tyrosine, N-Fmoc derivative; N-α-Fmoc-2-fluoro-L-tyrosine; Fmoc-Tyr(2-F)-OH; FMOC-L-TYR(2-F)-OH
EINECS	Contact for details

Quality Control

Our n-Fmoc-2-Fluoro-L-Tyrosine is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency, suitable for sensitive research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We ensure compliance with relevant industry standards and can provide material tailored to specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.