Description

D-2-Thiolhistidine is a specialized, sulfur-containing derivative of the amino acid histidine, distinguished by the presence of a thiol group on the imidazole ring. This unique structural modification makes it a valuable chiral building block and research chemical for advanced biochemical and pharmaceutical applications. It is particularly relevant for researchers and manufacturers in the fields of peptide synthesis, enzyme mechanism studies, and the development of novel therapeutic agents.

Application

• Pharmaceutical Research & Development: As a key intermediate in the synthesis of novel peptide-based drugs and enzyme inhibitors.
• Biochemical Studies: Used to investigate enzyme active sites, metal-binding properties, and redox biochemistry due to its reactive thiol group.
• Peptide Synthesis: Serves as a protected or unprotected chiral amino acid building block for solid-phase and solution-phase peptide synthesis.
• Proteomics & Metabolomics: Can be utilized as a standard or reagent in analytical studies of sulfur-containing amino acids and their metabolites.
• Nutritional Science Research: Investigated for its potential role and metabolism in specialized nutritional pathways.
• Chemical Biology Tool Development: Employed in the design of affinity labels, activity-based probes, and other chemical tools for probing biological systems.

Basic Information

Product Name	D-2-Thiolhistidine
CAS No.	1195264-93-7
Molecular Formula	C6H9N3O2S
Molecular Weight	187.22 g/mol
Synonyms	D-2-Mercaptohistidine; (R)-2-Thiolhistidine; (R)-2-Mercaptohistidine; D-2-SH-His; H-D-2-Thiolhis-OH; D-2-Thiohistidine; D-2-Thiol-His; D-enantiomer of 2-thiolhistidine
EINECS	Contact for details

Quality Control

Our D-2-Thiolhistidine is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for research and development applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles. We adhere to cGMP principles where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. Due to its sensitivity to oxidation, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep the container in a dry, well-ventilated place.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee (D-isomer)
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.