Description

(R)-cis-5ξ-Methyl Atracurium Dibesylate is a high-purity, stereochemically defined pharmaceutical intermediate and reference standard. This compound is critical for research and development in neuromuscular pharmacology and the synthesis of advanced neuromuscular blocking agents. It is primarily utilized by pharmaceutical R&D laboratories, analytical testing facilities, and manufacturers of active pharmaceutical ingredients (APIs) requiring precise stereochemical control.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel neuromuscular blocking agents and related pharmaceutical compounds.
• Reference Standard: Used for analytical method development, validation, and quality control (QC) testing in pharmaceutical manufacturing.
• Pharmacological Research: Essential for in-vitro and in-vivo studies investigating neuromuscular junction activity, receptor binding, and structure-activity relationships (SAR).
• Process Development: Serves as a critical material for scaling up synthetic routes and optimizing manufacturing processes under Good Manufacturing Practice (GMP) conditions.
• Impurity Profiling: Employed as a certified reference material to identify and quantify stereoisomeric impurities in atracurium besylate and related drug substances.

Basic Information

Product Name	(R)-cis-5ξ-Methyl Atracurium Dibesylate
CAS No.	1193104-82-3
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	(R)-cis-5-Methylatracurium dibesylate; (1R,1'R,2R,2'R)-2,2'-[1,5-Pentanediylbis[oxy(3-oxo-3,1-propanediyl)]]bis[1-[(3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methylisoquinolinium] dibenzenesulfonate; Stereoisomer of Atracurium besylate; (R,R)-cis-5-Methyl Atracurium Besylate; 5-Methylatracurium (R,R-cis) dibesylate salt
EINECS	Contact for details

Quality Control

Our (R)-cis-5ξ-Methyl Atracurium Dibesylate is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles, typically determined by advanced chromatographic (HPLC, chiral HPLC) and spectroscopic methods. We adhere to ICH guidelines for stability and impurity qualification, supporting its use in regulated pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0%
Water Content (KF)	≤2.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.