Description

(S)-n-Fmoc-2-(5'-Azido)Alanine CAS NO 1191429-12-5 is a specialized, non-natural amino acid derivative designed for advanced bioconjugation and peptide synthesis. This compound is engineered to introduce a bioorthogonal azido functional group at a specific position, enabling precise, site-specific modifications via click chemistry reactions like the Staudinger ligation or copper-catalyzed azide-alkyne cycloaddition (CuAAC). It is an essential building block for researchers and manufacturers in pharmaceutical development, proteomics, and chemical biology who require high-purity, structurally defined linkers for creating antibody-drug conjugates (ADCs), peptide-based therapeutics, and diagnostic probes.

Application

• Peptide Synthesis: A key protected amino acid for solid-phase peptide synthesis (SPPS), enabling the incorporation of a reactive azide handle into custom peptide sequences.
• Bioconjugation & ADC Development: Facilitates the site-specific attachment of payloads (e.g., toxins, fluorophores, drugs) to proteins, antibodies, or other biomolecules via click chemistry.
• Chemical Biology Probes: Used to synthesize activity-based probes (ABPs) or affinity tags for studying enzyme function, protein-protein interactions, and cellular localization.
• Materials Science: Serves as a functional monomer for creating smart polymers or surface coatings with bio-recognition properties.
• Diagnostic Reagent Formulation: Employed in the development of sensitive assay components, such as labeled antigens or detection antibodies.
• Academic & Industrial Research: A critical reagent for exploring new bioorthogonal reactions and developing novel therapeutic modalities.

Basic Information

Product Name	(S)-n-Fmoc-2-(5'-Azido)Alanine
CAS No.	1191429-12-5
Molecular Formula	C₁₈H₁₆N₄O₄
Molecular Weight	352.35 g/mol
Synonyms	Fmoc-5-Azido-L-norvaline; Fmoc-L-2-Amino-5-azidopentanoic Acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-5-azido-L-norvaline; (2S)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-5-azidopentanoic Acid; 5-Azido-L-norvaline, N-Fmoc derivative; Fmoc-5-N₃-L-norvaline; Fmoc-Azidoalanine derivative; Azido-Fmoc amino acid
EINECS	Contact for details

Quality Control

Our (S)-n-Fmoc-2-(5'-Azido)Alanine is manufactured under strict quality systems to ensure batch-to-batch consistency and high chemical purity, suitable for sensitive research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality protocols are designed to meet the stringent requirements of pharmaceutical and biotech customers. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) for long-term stability. This product is hygroscopic (moisture-sensitive) and light-sensitive; allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation. Keep container tightly sealed in a dry, cool, and well-ventilated place.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 95.0%
Assay	≥ 97.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.