Description

Fmoc-(S)-2-Me-Ser(Allyl)-Oh CAS NO 1191429-04-5 is a protected, non-proteinogenic amino acid derivative, specifically engineered for advanced solid-phase peptide synthesis (SPPS). This compound is critical for introducing the unique (S)-2-methylserine residue with an orthogonal allyl-protected side chain into complex peptide sequences, enabling precise structural control. It is an essential building block for pharmaceutical researchers and peptide manufacturers developing novel therapeutics, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the automated synthesis of complex peptides containing (S)-2-methylserine.
• Pharmaceutical Research & Development: Used in the discovery and production of peptide-based drugs, including hormone analogs, antimicrobial peptides, and targeted therapeutics.
• Bioconjugation & Chemical Biology: The allyl-protected side chain allows for selective deprotection and further functionalization, useful for creating peptide-drug conjugates or labeled probes.
• Peptidomimetic Design: Incorporates a methylated serine side chain to enhance metabolic stability, bioavailability, and receptor binding affinity in designed peptide mimics.
• Academic & Industrial Research: Serves as a specialized reagent for studying protein structure-function relationships and enzyme-substrate interactions.
• Custom Peptide Service Providers: A high-value raw material for CROs and CDMOs offering bespoke peptide synthesis services to the biotech and pharmaceutical industries.

Basic Information

Product Name	Fmoc-(S)-2-Me-Ser(Allyl)-Oh
CAS No.	1191429-04-5
Molecular Formula	C22H23NO5
Molecular Weight	381.42 g/mol
Synonyms	Fmoc-Ser(2-Me,Allyl)-OH; Fmoc-O-allyl-(S)-2-methylserine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-allyl-(S)-2-methylserine; (2S)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-3-[(2-propen-1-yl)oxy]-2-methylpropanoic acid; Fmoc-(S)-2-methyl-O-allyl-serine; Fmoc-2-Me-Ser(Allyl)-OH; Allyl O-[[(9H-fluoren-9-ylmethoxy)carbonyl]-2-methyl-L-seryl] ether
EINECS	Contact for details

Quality Control

Our Fmoc-(S)-2-Me-Ser(Allyl)-Oh is manufactured under strict quality systems to ensure the high purity and consistency required for sensitive peptide synthesis applications. Each batch is subjected to rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity, purity, and chiral integrity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and light-sensitive; ensure containers are sealed under inert atmosphere if specified and allowed to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.