Description

Fmoc-[D10]Leu-OH is a deuterium-labeled, protected amino acid derivative essential for advanced peptide synthesis. This compound is specifically engineered to provide high isotopic purity and structural integrity for research requiring mass spectrometry analysis and metabolic studies. It is a critical building block for pharmaceutical and biotechnology researchers developing peptide-based therapeutics, diagnostic agents, and stable isotope-labeled standards.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a deuterium-labeled Fmoc-protected leucine analog for the controlled incorporation of stable isotopes into peptide chains.
• Mass Spectrometry & Proteomics: Used to synthesize internal standards for accurate quantification and tracking in LC-MS/MS and MALDI-TOF applications.
• Metabolic Pathway Research: Enables the study of protein turnover, degradation rates, and metabolic flux analysis in biological systems.
• Pharmaceutical R&D: A key intermediate in the development of deuterated drug candidates to potentially enhance pharmacokinetic profiles.
• NMR Spectroscopy: Facilitates structural elucidation and dynamics studies of peptides and proteins by providing sites for specific isotopic labeling.
• Bioconjugation & Probe Development: Serves as a precursor for creating labeled peptides used in imaging, targeting, and diagnostic probes.

Basic Information

Product Name	Fmoc-[D10]Leu-OH
CAS No.	1190594-22-9
Molecular Formula	C₂₁H₁₁D₁₀NO₄
Molecular Weight	369.45 g/mol (for unlabeled form; exact mass varies with isotopic enrichment)
Synonyms	Fmoc-D10-leucine; N-(9-Fluorenylmethoxycarbonyl)-perdeuteroleucine; Fmoc-perdeutero-L-leucine; (2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-4,4,5,5,6,6,6-heptadeutero-4-methylpentanoic acid; N-α-Fmoc-L-leucine-d10; Fmoc-L-leucine(d10); Fmoc-Leu(D10)-OH; Deuterated Fmoc-Leu-OH
EINECS	Contact for details

Quality Control

Our Fmoc-[D10]Leu-OH is produced under strict quality management systems to ensure batch-to-batch consistency and high isotopic purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing parameters such as chemical purity (by HPLC), isotopic enrichment (by NMR or MS), chiral purity, and moisture content. We support research and development requiring reliable and well-characterized labeled building blocks.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This material is hygroscopic (moisture-sensitive). Allow the sealed container to equilibrate to room temperature before opening to minimize condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Optical Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.