Description

2-Pyrrolidinyl Desmorpholinylrocuronium Bromide is a high-purity, non-depolarizing neuromuscular blocking agent derivative, primarily utilized in advanced pharmacological research and development. This compound is critical for studying neuromuscular junction physiology and for the development of novel anesthetic adjuvants or reversal agents. It is essential for pharmaceutical R&D laboratories, academic research institutions, and companies specializing in the synthesis of active pharmaceutical ingredients (APIs) for anesthesia and critical care medicine.

Application

• Pharmaceutical Research & Development: Serves as a key intermediate or reference standard in the synthesis and study of new neuromuscular blocking agents and their antagonists.
• Mechanistic Studies: Used in in vitro and ex vivo models to investigate the kinetics and dynamics of nicotinic acetylcholine receptor blockade at the neuromuscular junction.
• Analytical Method Development: Employed as a certified reference material (CRM) for developing and validating precise HPLC, LC-MS, or other chromatographic assays in bioanalytical laboratories.
• Preclinical Toxicology: Utilized in safety pharmacology studies to assess the cardiovascular and respiratory side-effect profiles of new chemical entities targeting neuromuscular pathways.
• Process Chemistry: Acts as a building block or a comparative marker for optimizing synthetic routes for rocuronium bromide analogs under Good Manufacturing Practice (GMP) conditions.

Basic Information

Product Name	2-Pyrrolidinyl Desmorpholinylrocuronium Bromide
CAS No.	1190105-65-7
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Desmorpholinylrocuronium Bromide; 2-Pyrrolidinyl Derivative of Rocuronium Bromide; Rocuronium Bromide Impurity; Rocuronium Related Compound; 1-[17β-(Acetyloxy)-3α-hydroxy-2β-(4-morpholinyl)-5α-androstan-16β-yl]-1-(2-pyrrolidinyl) Pyrrolidinium Bromide; Androstan-16β-yl Pyrrolidinium Bromide Derivative; Neuromuscular Blocker Intermediate
EINECS	Contact for details

Quality Control

Every batch of 2-Pyrrolidinyl Desmorpholinylrocuronium Bromide is manufactured and analyzed under strict quality management systems. Our products undergo rigorous quality testing to ensure compliance with industry standards for research chemicals. Comprehensive testing includes identity confirmation, purity assay, and control of specific impurities. Certificates of Analysis (COA) detailing all analytical results are available upon request to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccant use and storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Purity (HPLC, Area %)	≥ 97.0%
Single Unknown Impurity	≤ 1.0%
Total Impurities	≤ 3.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 5.0% w/w

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.