Description

4-Chloro-6-Pyrrolidin-1-Yl-2-Trifluoromethylpyrimidine is a high-value pyrimidine-based building block, distinguished by its trifluoromethyl and pyrrolidine substituents which confer unique electronic and steric properties. This compound is essential for advanced research and development in medicinal chemistry, particularly in the synthesis of novel small molecule therapeutics. It is primarily sought after by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in creating targeted drug candidates, especially in oncology and central nervous system (CNS) disease areas.

Application

• Pharmaceutical Intermediate: A key synthetic precursor for the development of kinase inhibitors and other biologically active molecules.
• Agrochemical Research: Used in the discovery and synthesis of new active ingredients for crop protection products.
• Material Science: Serves as a building block for advanced organic electronic materials and liquid crystals.
• Chemical Biology: Employed as a probe or ligand in the study of enzyme mechanisms and protein interactions.
• Custom Synthesis: A versatile starting material for contract research organizations (CROs) and CDMOs performing bespoke chemical synthesis.

Basic Information

Product Name	4-Chloro-6-Pyrrolidin-1-Yl-2-Trifluoromethylpyrimidine
CAS No.	1189872-15-8
Molecular Formula	C9H10ClF3N3
Molecular Weight	264.65 g/mol
Synonyms	4-Chloro-6-(pyrrolidin-1-yl)-2-(trifluoromethyl)pyrimidine; 2-(Trifluoromethyl)-4-chloro-6-(1-pyrrolidinyl)pyrimidine; 4-Chloro-6-pyrrolidin-1-yl-2-trifluoromethyl-pyrimidine; 1189872-15-8; 4-Chloro-6-(N-pyrrolidino)-2-trifluoromethylpyrimidine
EINECS	Contact for details

Quality Control

Our 4-Chloro-6-Pyrrolidin-1-Yl-2-Trifluoromethylpyrimidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with every shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for advanced pharmaceutical intermediates, ensuring reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.