Description

(4R)-4-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)Pentanoic Acid is a high-purity, non-natural amino acid derivative featuring an Fmoc-protected amine group and a carboxylic acid terminus. This compound is a critical chiral building block designed for the controlled synthesis of complex peptides and peptidomimetics, offering precise stereochemical control. It is essential for researchers and manufacturers in pharmaceutical development, proteomics, and advanced materials science who require reliable, high-quality intermediates for solid-phase peptide synthesis (SPPS) and other specialized organic syntheses.

Application

• Solid-Phase Peptide Synthesis (SPPS): Serves as a key chiral Fmoc-protected amino acid building block for the automated synthesis of therapeutic peptides and peptide libraries.
• Pharmaceutical Intermediates: Used in the research and development of novel active pharmaceutical ingredients (APIs), particularly for oncology, metabolic disorders, and hormonal therapies.
• Peptidomimetic Design: Enables the creation of modified peptide structures with enhanced stability, bioavailability, and target specificity for drug discovery programs.
• Bioconjugation & Labeling: The carboxylic acid group facilitates conjugation to other molecules, carriers, or surfaces for creating diagnostic probes or targeted delivery systems.
• Academic & Industrial Research: A valuable tool in chemical biology for studying protein-protein interactions and enzyme mechanisms.
• Custom Oligomer Synthesis: Employed in the production of specialized non-standard peptides for research and diagnostic applications.

Basic Information

Product Name	(4R)-4-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)Pentanoic Acid
CAS No.	1189357-66-1
Molecular Formula	C20H21NO4
Molecular Weight	339.39 g/mol
Synonyms	Fmoc-D-Homoglutamic Acid 5-tert-Butyl Ester; Fmoc-D-hGlu(OtBu)-OH; (R)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)pentanedioic acid 5-tert-butyl ester; Fmoc-D-2-aminopentanedioic acid 5-tert-butyl ester; (4R)-4-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-5-tert-butoxy-5-oxopentanoic acid; Fmoc-D-Glu(OtBu)-OH (common designation for this stereoisomer and protection pattern); D-Fmoc-homoglutamic acid γ-tert-butyl ester
EINECS	Contact for details

Quality Control

Our (4R)-4-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)Pentanoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting standards for peptide synthesis intermediates. A comprehensive Certificate of Analysis (COA) detailing identity, purity (typically ≥98%), chiral excess, and impurity profiles is provided with every shipment to guarantee batch-to-batch consistency and support your regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.