Description

(Pyr1)-Opiorphin is a synthetic, modified peptide analog of the endogenous human pentapeptide opiorphin, designed for enhanced stability and research utility. This compound is a valuable pharmacological tool for investigating the enkephalinase inhibition pathway and its associated physiological effects. It is primarily utilized by researchers and developers in the fields of neuroscience, pharmacology, and analgesic drug discovery to study pain modulation and develop novel therapeutic agents.

Application

• Neuroscience Research: As a key tool compound for studying the role of endogenous opioid systems in pain perception and central nervous system signaling.
• Analgesic Drug Discovery: Serving as a reference standard or lead compound in the development of new, non-opioid pain relievers that target enkephalinase inhibition.
• Pharmacological Assays: Used in in vitro and in vivo studies to validate assay systems and investigate the mechanism of action of enkephalinase inhibitors.
• Biochemical Studies: Employed to explore the structure-activity relationships (SAR) of opiorphin analogs and their interaction with target enzymes.
• Reference Standard: For quality control and analytical method development in pharmaceutical R&D laboratories.

Basic Information

Product Name	(Pyr1)-Opiorphin
CAS No.	1189350-60-4
Molecular Formula	C30H46N8O7S
Molecular Weight	638.8 g/mol
Synonyms	Pyroglutamyl-Phe-Arg-Pro-Ser-Arg-NH2; Pyr1-Opiorphin; (Pyr)FRPSR-NH2; 1-Pyroglutamyl-Phe-Arg-Pro-Ser-Arg-amide; Opiorphin (pyr1-); Modified Opiorphin; Synthetic Opiorphin analog; Human opiorphin (1-5), 1-L-pyroglutamyl-
EINECS	Contact for details

Quality Control

Our (Pyr1)-Opiorphin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and tests for residual solvents and moisture content. We provide a comprehensive Certificate of Analysis (COA) with each shipment, detailing all specifications and test results to ensure traceability and compliance with your research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.