Description

Ethyl 4-Chloro-7-Methoxyquinazoline-2-Carboxylate is a high-purity, advanced pharmaceutical intermediate with the CAS registry number 1189107-22-9. This compound is a critical building block in the synthesis of targeted kinase inhibitors, offering researchers and manufacturers a reliable starting material for complex drug discovery and development programs. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical producers engaged in the creation of novel therapeutic agents, particularly in oncology and other disease areas involving kinase modulation.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of potent and selective kinase inhibitors for targeted cancer therapies.
• Drug Discovery Research: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the development of new chemical entities (NCEs) targeting EGFR, VEGFR, and other kinase families.
• Process Chemistry & Scale-Up: Serves as a standardized building block for process optimization and the commercial-scale manufacturing of active pharmaceutical ingredients (APIs).
• Biochemical Tool Compound: Employed in biochemical assays to study kinase function, signal transduction pathways, and for high-throughput screening (HTS) campaigns.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of client-specific molecules under cGMP or research-grade conditions.

Basic Information

Item	Details
Product Name	Ethyl 4-Chloro-7-Methoxyquinazoline-2-Carboxylate
CAS No.	1189107-22-9
Molecular Formula	C₁₂H₁₁ClN₂O₃
Molecular Weight	266.68 g/mol
Synonyms	4-Chloro-7-methoxyquinazoline-2-carboxylic acid ethyl ester; Ethyl 4-chloro-7-methoxy-2-quinazolinecarboxylate; 2-Quinazolinecarboxylic acid, 4-chloro-7-methoxy-, ethyl ester; 1189107-22-9; 4-Chloro-7-methoxyquinoline-2-carboxylate ethyl ester (common misnomer); 7-Methoxy-4-chloroquinazoline-2-carboxylic acid ethyl ester
EINECS	Contact for details

Quality Control

Every batch of Ethyl 4-Chloro-7-Methoxyquinazoline-2-Carboxylate is produced and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for pharmaceutical research and development. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is supplied with each shipment, and we can support custom specifications for advanced applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and stored in the original packaging away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.