Description

Octa(Otbu)-Glu-Otbu is a high-purity, protected glutamic acid derivative, specifically designed for advanced peptide synthesis and organic chemistry applications. This compound is valued for its role as a key building block, offering orthogonal protection strategies that enable precise molecular assembly. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors who require reliable, high-quality intermediates for complex molecule development.

Application

• Solid-Phase Peptide Synthesis (SPPS): Serves as a crucial, protected glutamic acid residue for the controlled construction of complex peptides and proteins.
• Solution-Phase Organic Synthesis: Used as a versatile intermediate in the synthesis of custom amino acid derivatives and small molecule conjugates.
• Pharmaceutical Intermediate: A key raw material in the research and development of novel therapeutic peptides and peptidomimetics.
• Bioconjugation Chemistry: Facilitates the site-specific modification of biomolecules for drug delivery systems and diagnostic probes.
• Chemical Biology Research: Employed in the study of protein-protein interactions and enzyme mechanisms using synthetic peptide tools.
• Fine Chemical Production: Acts as a specialized building block for synthesizing high-value, non-natural amino acids and chiral compounds.

Basic Information

Product Name	Octa(Otbu)-Glu-Otbu
CAS No.	1188328-39-3
Molecular Formula	C52H96N2O21
Molecular Weight	1109.33 g/mol
Synonyms	Fmoc-Glu(OtBu)-OtBu; N-α-Fmoc-L-glutamic acid 1,5-di-tert-butyl ester; Fmoc-Glu(OtBu)-OtBu; Fmoc-L-glutamic acid α,γ-di-tert-butyl ester; N-(9-Fluorenylmethoxycarbonyl)-L-glutamic acid 1,5-di-tert-butyl ester; Fmoc-Glu(OtBu)2-OH; Fmoc-Glu(OtBu)-O-tBu; Fmoc-Glutamic Acid Di-tert-butyl Ester
EINECS	Contact for details

Quality Control

Our Octa(Otbu)-Glu-Otbu is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for fine chemical intermediates, and specifications can be tailored to meet specific project requirements for research and cGMP manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥ 98.0%
Specific Rotation	-15.0° to -18.0° (c=1 in DMF)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.