Description

8-Fluoro-4,4-Dimethyl-1,2,3,4-Tetrahydroquinoline is a fluorinated tetrahydroquinoline derivative, a privileged scaffold in medicinal chemistry. This compound matters as a key synthetic intermediate for developing novel active pharmaceutical ingredients (APIs), leveraging the fluorine atom to modulate the biological activity, metabolic stability, and lipophilicity of target molecules. It is primarily needed by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of agrochemicals, advanced materials, and complex organic molecules.

Application

• Pharmaceutical Intermediate: Serves as a critical building block for the synthesis of drug candidates targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, where the fluorine atom enhances bioactivity and environmental persistence.
• Material Science: Acts as a precursor for functionalized organic molecules used in advanced materials, such as organic light-emitting diodes (OLEDs) and liquid crystals.
• Chemical Biology Probe Development: Employed in creating fluorescent tags or molecular probes for studying biological processes and enzyme mechanisms.
• Academic & Contract Research: Essential for universities and CROs (Contract Research Organizations) conducting research in synthetic organic chemistry and medicinal chemistry.
• Custom Synthesis: A starting material for the custom manufacturing of complex, fluorinated heterocyclic compounds for client-specific projects.

Basic Information

Product Name	8-Fluoro-4,4-Dimethyl-1,2,3,4-Tetrahydroquinoline
CAS No.	1187933-45-4
Molecular Formula	C11H14FN
Molecular Weight	179.24 g/mol
Synonyms	8-Fluoro-4,4-dimethyl-1,2,3,4-tetrahydroquinoline; 4,4-Dimethyl-8-fluoro-1,2,3,4-tetrahydroquinoline; 1,2,3,4-Tetrahydro-8-fluoro-4,4-dimethylquinoline; 8-Fluoro-4,4-dimethyl-3,4-dihydro-2H-quinoline; 8-Fluoro-4,4-dimethyl-1,2,3,4-tetrahydro-quinoline; FDTQ; 8-F-4,4-DMTHQ
EINECS	Contact for details

Quality Control

Our 8-Fluoro-4,4-Dimethyl-1,2,3,4-Tetrahydroquinoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability and batch-to-batch consistency for critical R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.