Description

(1S)-2,2,2-Trifluoro-1-(4-Methylphenyl)Ethylamine is a high-purity chiral amine building block featuring a trifluoromethyl group and a p-tolyl substituent. This compound is of significant commercial interest due to its role as a critical intermediate in the synthesis of advanced pharmaceutical active ingredients and agrochemicals. It is primarily sought by R&D chemists and process development teams in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecules with enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the development of active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and antiviral drug candidates.
• Agrochemical Synthesis: Building block for novel herbicides, fungicides, and insecticides where the trifluoromethyl group imparts improved lipophilicity and biological activity.
• Ligand and Catalyst Preparation: Used in the synthesis of chiral ligands for asymmetric catalysis and organocatalysts.
• Material Science Research: Intermediate for creating specialty polymers and advanced organic materials with unique fluorinated properties.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme mechanisms and biological pathways.

Basic Information

Product Name	(1S)-2,2,2-Trifluoro-1-(4-Methylphenyl)Ethylamine
CAS No.	1187930-94-4
Molecular Formula	C9H10F3N
Molecular Weight	189.18 g/mol
Synonyms	(S)-1-(4-Methylphenyl)-2,2,2-trifluoroethanamine; (S)-α-(Trifluoromethyl)-4-methylbenzylamine; (S)-1-(p-Tolyl)-2,2,2-trifluoroethylamine; (1S)-1-[4-Methylphenyl]-2,2,2-trifluoroethanamine; (S)-4-Methyl-α-(trifluoromethyl)benzylamine; (S)-TFMA; (S)-Trifluoromethyl p-tolylmethylamine; (S)-1-(4-Methylphenyl)-2,2,2-trifluoroethylamine
EINECS	Contact for details

Quality Control

Our (1S)-2,2,2-Trifluoro-1-(4-Methylphenyl)Ethylamine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity (HPLC), chemical purity (GC/HPLC), and identity confirmation (NMR, IR, MS) to ensure it meets the stringent requirements for pharmaceutical R&D and process chemistry. Certificates of Analysis (COA) with full traceability are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.