Description

(R)-2,2,2-Trifluoro-1-(4-Fluorophenyl)Ethanamine is a high-value chiral building block featuring a trifluoromethyl group and a fluorinated aromatic ring, which are critical motifs in modern medicinal chemistry. This compound is essential for the synthesis of active pharmaceutical ingredients (APIs) and advanced intermediates, where its stereochemistry and fluorine atoms can dramatically influence a drug's metabolic stability, bioavailability, and binding affinity. It is primarily sought after by pharmaceutical R&D teams and fine chemical manufacturers developing novel therapeutics, particularly in the areas of central nervous system (CNS) agents, anti-inflammatory drugs, and enzyme inhibitors.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel Active Pharmaceutical Ingredients (APIs).
• Agrochemical Synthesis: Used in creating advanced intermediates for new-generation herbicides and pesticides with enhanced efficacy.
• Ligand & Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Fluorinated Compound Library: A critical component in building diverse screening libraries for drug discovery programs.
• Material Science Research: Investigated as a monomer or additive for developing specialty polymers with unique surface properties.
• Diagnostic Agent Precursor: Potential use in synthesizing radiolabeled compounds or contrast agents for medical imaging.

Basic Information

Product Name	(R)-2,2,2-Trifluoro-1-(4-Fluorophenyl)Ethanamine
CAS No.	1187928-45-5
Molecular Formula	C8H7F4N
Molecular Weight	193.14 g/mol
Synonyms	(R)-1-(4-Fluorophenyl)-2,2,2-trifluoroethanamine; (R)-α,α,α-Trifluoro-4-fluoro-phenethylamine; (R)-2,2,2-Trifluoro-1-(4-fluorophenyl)ethylamine; (R)-4-Fluoro-α-(trifluoromethyl)benzylamine; (R)-1-(4-Fluorophenyl)-2,2,2-trifluoroethylamine; (R)-F-Phenyl-CF3-ethylamine; (R)-F-Phe-CF3-NH2; (R)-4-Fluoro-α-(trifluoromethyl)benzenemethanamine
EINECS	Contact for details

Quality Control

Our (R)-2,2,2-Trifluoro-1-(4-Fluorophenyl)Ethanamine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including chiral HPLC to ensure high enantiomeric excess (ee) and identity confirmation via NMR and MS. We provide full traceability and Certificates of Analysis (COA) are available upon request, detailing purity, assay, and impurity profiles to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen) for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.