Description

2,4-Dichloro-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine hydrochloride is a high-purity, heterocyclic organic compound that serves as a critical building block in advanced pharmaceutical synthesis. Its value lies in its functionalized pyridopyrimidine core, which is a privileged scaffold for developing potent and selective small-molecule therapeutics. This intermediate is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly those focused on oncology, kinase inhibitors, and other targeted drug discovery programs.

Application

• Pharmaceutical Intermediate: A key synthetic precursor for the development of novel active pharmaceutical ingredients (APIs), especially kinase inhibitors.
• Drug Discovery Research: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization in various therapeutic areas.
• Chemical Biology Probe Synthesis: Employed in the creation of molecular probes to study biological pathways and protein functions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of clinical trial materials and commercial APIs.
• Academic Research: Utilized in university and institutional labs for fundamental research in organic chemistry and heterocyclic compound development.

Basic Information

Product Name	2,4-Dichloro-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine Hydrochloride
CAS No.	1187830-76-7
Molecular Formula	C7H8Cl3N3
Molecular Weight	248.52 g/mol
Synonyms	2,4-Dichloro-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine HCl; 2,4-Dichloro-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine monohydrochloride; 5,6,7,8-Tetrahydro-2,4-dichloropyrido[3,4-d]pyrimidine hydrochloride; Pyrido[3,4-d]pyrimidine, 2,4-dichloro-5,6,7,8-tetrahydro-, hydrochloride (1:1); 1187830-76-7; 2,4-Dichloro-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine hydrochloride salt
EINECS	Contact for details

Quality Control

Our 2,4-Dichloro-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine hydrochloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for demanding research and development applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to industry best practices, and specifications can be aligned with customer-specific requirements for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.