Description

(4-(1-(3-(Cyanomethyl)-1-(Ethylsulfonyl)Azetidin-3-Yl)-1H-Pyrazol-4-Yl)-7H-Pyrrolo[2,3-D]Pyrimidin-7-Yl)Methyl Pivalate is a sophisticated heterocyclic organic compound featuring a pyrrolopyrimidine core, a key structural motif in medicinal chemistry. This high-purity advanced intermediate is critical for pharmaceutical research and development, particularly in the synthesis of targeted kinase inhibitors. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries for the creation of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the multi-step synthesis of potential drug candidates, especially kinase inhibitors.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs to develop new chemical entities.
• Process Chemistry Development: Employed in scaling up synthetic routes from laboratory to pilot plant scale for clinical trial material production.
• Biochemical Probe Synthesis: A precursor for creating specialized molecules used to study biological pathways and enzyme functions.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting global drug discovery pipelines.
• Academic Research: Used in university and institutional labs for cutting-edge research in organic synthesis and chemical biology.

Basic Information

Product Name	(4-(1-(3-(Cyanomethyl)-1-(Ethylsulfonyl)Azetidin-3-Yl)-1H-Pyrazol-4-Yl)-7H-Pyrrolo[2,3-D]Pyrimidin-7-Yl)Methyl Pivalate
CAS No.	1187595-90-9
Molecular Formula	C23H27N7O4S
Molecular Weight	497.57 g/mol
Synonyms	7-(((2,2-Dimethylpropanoyl)oxy)methyl)-4-[1-[3-(cyanomethyl)-1-(ethylsulfonyl)azetidin-3-yl]pyrazol-4-yl]pyrrolo[2,3-d]pyrimidine; Pivalic acid [(4-(1-(3-(cyanomethyl)-1-(ethylsulfonyl)azetidin-3-yl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)]methyl ester; 1187595-90-9; UNII-9F2G0K8W1T; 9F2G0K8W1T; AKOS025147064; CS-0446646; (4-(1-(3-(Cyanomethyl)-1-(ethanesulfonyl)azetidin-3-yl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate
EINECS	Contact for details

Quality Control

Our production of (4-(1-(3-(Cyanomethyl)-1-(Ethylsulfonyl)Azetidin-3-Yl)-1H-Pyrazol-4-Yl)-7H-Pyrrolo[2,3-D]Pyrimidin-7-Yl)Methyl Pivalate adheres to stringent quality systems suitable for pharmaceutical development. Each batch undergoes comprehensive analytical characterization to ensure identity, purity, and consistency. Certificates of Analysis (COA) are provided, detailing results from HPLC, NMR, and MS analyses. We support compliance with cGMP guidelines for advanced intermediates and can tailor purity specifications to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C under an inert atmosphere. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture uptake. Store in a cool, dry, well-ventilated area away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.