Description

3-Azetidineacetonitrile, 1-(Ethylsulfonyl)-3-[4-[7-(Hydroxymethyl)-7H-Pyrrolo[2,3-D]Pyrimidin-4-Yl]-1H-Pyrazol-1-Yl]- is a high-purity, advanced pharmaceutical intermediate featuring a complex heterocyclic structure. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of targeted kinase inhibitors. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of novel therapeutic agents for oncology and other disease areas.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel kinase inhibitors for oncology research.
• Medicinal Chemistry R&D: Used in structure-activity relationship (SAR) studies and lead optimization for drug discovery programs.
• Bioconjugation & Probe Development: Serves as a precursor for creating labeled compounds and biochemical probes for target validation.
• Preclinical Candidate Synthesis: Employed in the scale-up synthesis of drug candidates for preclinical and early-phase clinical studies.
• Custom Synthesis: Used by CDMOs (Contract Development and Manufacturing Organizations) for client-specific custom synthesis projects.
• Academic Research: Utilized in university and institutional labs for fundamental research in chemical biology and therapeutic mechanisms.

Basic Information

Product Name	3-Azetidineacetonitrile, 1-(Ethylsulfonyl)-3-[4-[7-(Hydroxymethyl)-7H-Pyrrolo[2,3-D]Pyrimidin-4-Yl]-1H-Pyrazol-1-Yl]-
CAS No.	1187595-89-6
Molecular Formula	C17H18N6O3S
Molecular Weight	386.43 g/mol
Synonyms	1-(Ethylsulfonyl)-3-[4-[7-(hydroxymethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-1H-pyrazol-1-yl]azetidine-3-acetonitrile; 1-(Ethylsulfonyl)-3-[4-(7-hydroxymethyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]azetidine-3-acetonitrile; Azetidine-3-acetonitrile, 1-(ethylsulfonyl)-3-[4-[7-(hydroxymethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-1H-pyrazol-1-yl]-; 1187595-89-6; UNII-9I3J8B3P4F
EINECS	Contact for details

Quality Control

Our 3-Azetidineacetonitrile derivative is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for demanding research applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP (current Good Manufacturing Practice) guidelines where applicable, and our quality protocols are designed to meet the stringent requirements of pharmaceutical development partners.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.