Description

4-Fluoro-n-Methyl-3-(Trifluoromethyl)Aniline Hydrochloride is a high-value fluorinated aromatic amine salt, serving as a critical building block in advanced organic synthesis. Its molecular structure, featuring both fluorine and trifluoromethyl groups, is engineered to impart enhanced metabolic stability, lipophilicity, and bioavailability to target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of novel active pharmaceutical ingredients (APIs) and crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon for the development of fluorinated drug candidates, including kinase inhibitors, antiviral agents, and central nervous system (CNS) active compounds.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the fluorine moiety improves environmental persistence and biological activity.
• Material Science Precursor: Employed in the synthesis of specialty polymers, liquid crystals, and organic electronic materials requiring fluorinated aromatic components.
• Chemical Research & Development: Serves as a versatile reagent for introducing the 4-fluoro-3-(trifluoromethyl)aniline moiety into complex molecular architectures in medicinal and process chemistry.

Basic Information

Product Name	4-Fluoro-n-Methyl-3-(Trifluoromethyl)Aniline Hydrochloride
CAS No.	1187386-25-9
Molecular Formula	C9H8ClF4N
Molecular Weight	241.61 g/mol
Synonyms	4-Fluoro-N-methyl-3-(trifluoromethyl)aniline hydrochloride; 3-(Trifluoromethyl)-4-fluoro-N-methylaniline hydrochloride; 4-Fluoro-3-(trifluoromethyl)-N-methylbenzenamine hydrochloride; N-Methyl-4-fluoro-3-(trifluoromethyl)aniline HCl; 1-Fluoro-2-methylamino-5-(trifluoromethyl)benzene hydrochloride; Benzenamine, 4-fluoro-N-methyl-3-(trifluoromethyl)-, hydrochloride; CAS 1187386-25-9
EINECS	Contact for details

Quality Control

Our 4-Fluoro-n-Methyl-3-(Trifluoromethyl)Aniline Hydrochloride is manufactured under strict quality management systems. Each batch is subjected to rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply for critical R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong bases and strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%; Any single impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.