Description

3-Chloro-2-Fluoro-n-Methylaniline Hydrochloride is a high-purity, halogenated aniline derivative salt of significant importance in advanced organic synthesis. Its value lies in its role as a versatile and critical building block for constructing complex molecular architectures, particularly in the pharmaceutical and agrochemical sectors. This compound is essential for research chemists and process development scientists working on active pharmaceutical ingredients (APIs), crop protection agents, and specialty dyes.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the chloro-fluoro substitution pattern enhances biological activity and environmental stability.
• Material Science Research: Serves as a monomer or precursor for advanced polymers, liquid crystals, and organic electronic materials requiring specific halogenated aromatic units.
• Dye and Pigment Manufacturing: Acts as an intermediate for producing high-performance, light-fast azo dyes and complex organic pigments.
• Chemical Research & Development: Employed in academic and industrial R&D for methodological studies in cross-coupling reactions, amination, and other catalytic transformations.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds and scaled-up processes.

Basic Information

Product Name	3-Chloro-2-Fluoro-n-Methylaniline Hydrochloride
CAS No.	1187386-17-9
Molecular Formula	C7H8Cl2FN
Molecular Weight	204.05 g/mol
Synonyms	3-Chloro-2-fluoro-N-methylaniline hydrochloride; 1-(3-Chloro-2-fluorophenyl)-N-methylmethanamine hydrochloride; N-Methyl-3-chloro-2-fluoroaniline hydrochloride; 3-Chloro-2-fluoro-N-methylbenzenamine hydrochloride; Benzenamine, 3-chloro-2-fluoro-N-methyl-, hydrochloride (1:1); 2-Fluoro-3-chloro-N-methylaniline HCl
EINECS	Contact for details

Quality Control

Our production of 3-Chloro-2-Fluoro-n-Methylaniline Hydrochloride adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for moisture content. We provide detailed Certificates of Analysis (COA) with each shipment, ensuring traceability and compliance with customer specifications and cGMP guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen) after initial opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.