Description

2,4-Difluoro-n-Methylaniline Hydrochloride is a high-purity, halogenated aniline derivative salt, serving as a critical building block in advanced organic synthesis. Its value lies in providing a functionalized aromatic amine core with enhanced reactivity and selectivity for constructing complex molecules. This intermediate is essential for research and development chemists and process engineers in the pharmaceutical and agrochemical industries, particularly for the synthesis of active pharmaceutical ingredients (APIs) and novel crop protection agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of fluorinated drug candidates, including kinase inhibitors, antibacterial agents, and central nervous system (CNS) active compounds.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and pesticides, where the difluoro substitution pattern can improve bioavailability and environmental stability.
• Material Science Research: Employed in the creation of specialty polymers, liquid crystals, and organic electronic materials that require fluorinated aromatic components.
• Chemical Biology & Proteomics: Acts as a versatile scaffold for designing fluorescent probes, affinity labels, and other molecular tools for biochemical research.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and production under cGMP conditions.

Basic Information

Product Name	2,4-Difluoro-n-Methylaniline Hydrochloride
CAS No.	1187386-15-7
Molecular Formula	C7H8ClF2N
Molecular Weight	179.59 g/mol
Synonyms	N-Methyl-2,4-difluoroaniline hydrochloride; 2,4-Difluoro-N-methylaniline HCl; 2,4-Difluoro-N-methylbenzenamine hydrochloride; 1-Methylamino-2,4-difluorobenzene hydrochloride; 2,4-DFMA HCl; (2,4-Difluorophenyl)(methyl)amine hydrochloride
EINECS	Contact for details

Quality Control

Every batch of 2,4-Difluoro-n-Methylaniline Hydrochloride is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure identity, purity, and consistency, supporting regulatory filings and process validation. A detailed Certificate of Analysis (COA) with results from HPLC, NMR, and Karl Fischer titration is supplied with each shipment, confirming compliance with customer specifications and industry best practices.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after initial opening to prevent degradation. Keep away from incompatible materials such as strong bases and strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.