Description

1-(3,4-Difluorophenyl)Cyclopropylamine Hydrochloride is a high-purity, advanced pharmaceutical intermediate characterized by its cyclopropylamine core and difluorinated aromatic system. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring specific molecular geometry and fluorine substitution. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of central nervous system (CNS) agents, antiviral drugs, and other specialized small-molecule therapeutics.

Application

• Pharmaceutical Intermediate: A key synthon in the research and commercial synthesis of novel drug candidates, especially those targeting neurological and psychiatric disorders.
• Agrochemical Research: Serves as a precursor in the development of new-generation pesticides and herbicides, leveraging the biological activity of the cyclopropylamine moiety.
• Material Science: Used in the synthesis of specialized monomers or ligands for advanced polymers and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Employed in the creation of molecular probes for studying enzyme mechanisms and receptor interactions in biochemical research.
• Process Chemistry & Scale-Up: Supplied for route scouting, optimization, and cGMP manufacturing of clinical trial materials and commercial APIs.

Basic Information

Product Name	1-(3,4-Difluorophenyl)Cyclopropylamine Hydrochloride
CAS No.	1186663-16-0
Molecular Formula	C9H10ClF2N
Molecular Weight	205.63 g/mol
Synonyms	1-(3,4-Difluorophenyl)cyclopropanamine hydrochloride; 1-(3,4-Difluorophenyl)cyclopropylamine HCl; 3,4-Difluoro-1-cyclopropylbenzenamine hydrochloride; Cyclopropyl(3,4-difluorophenyl)amine hydrochloride; 1-Cyclopropyl-3,4-difluoroaniline hydrochloride; (3,4-Difluorophenyl)cyclopropylamine hydrochloride; 1186663-16-0; UNII-9G6F6X8Q3S
EINECS	Contact for details

Quality Control

Our 1-(3,4-Difluorophenyl)Cyclopropylamine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and stringent controls for residual solvents and related substances. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.