Description

7-(tert-Butyl)-2,4-Bis(trifluoromethyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carboxamide is a high-value, fluorinated heterocyclic building block of significant interest in advanced organic synthesis. Its core pyrrolopyrimidine scaffold, functionalized with electron-withdrawing trifluoromethyl groups and a sterically hindered tert-butyl moiety, makes it a critical intermediate for developing novel bioactive compounds. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of new drug candidates and crop protection agents with enhanced properties.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other targeted therapies.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides, where the fluorine atoms and heterocyclic core can improve metabolic stability and binding affinity.
• Material Science Precursor: Potential building block for advanced organic electronic materials, such as organic light-emitting diodes (OLEDs) or semiconductors, due to its conjugated system and fluorine content.
• Chemical Biology Probe: Employed in the design and synthesis of molecular probes for studying biological pathways and target engagement in drug discovery.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds for client projects.
• Academic & Institutional Research: Utilized in university and government laboratories for fundamental research in medicinal chemistry and synthetic methodology development.

Basic Information

Product Name	7-(tert-Butyl)-2,4-Bis(trifluoromethyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carboxamide
CAS No.	1186404-55-6
Molecular Formula	C14H13F6N5O
Molecular Weight	381.28 g/mol
Synonyms	7H-Pyrrolo[2,3-d]pyrimidine-5-carboxamide, 7-(1,1-dimethylethyl)-2,4-bis(trifluoromethyl)-; 7-tert-Butyl-2,4-bis(trifluoromethyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carboxamide; 1186404-55-6; 7-(tert-Butyl)-2,4-bis(trifluoromethyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylic acid amide; 7-tert-Butyl-2,4-di(trifluoromethyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carboxamide
EINECS	Contact for details

Quality Control

Our production of 7-(tert-Butyl)-2,4-Bis(trifluoromethyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carboxamide adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical characterization using techniques including HPLC, NMR, and MS to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific client or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This compound may be sensitive to strong bases and fluorides; keep away from incompatible materials. For long-term storage, consider inert atmosphere conditions to ensure optimal stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.