Description

7-(3-Amino-Phenyl)-Pyrazolo[1,5-A]Pyrimidine-3-Carboxylic Acid Ethyl Ester Hydrochloride is a high-purity, advanced pharmaceutical intermediate belonging to the pyrazolopyrimidine class of heterocyclic compounds. This compound is a critical building block in the synthesis of novel, targeted therapeutic agents, offering researchers and manufacturers a reliable and well-characterized starting material. It is primarily utilized by pharmaceutical R&D teams and fine chemical producers engaged in developing kinase inhibitors and other small molecule drugs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) for targeted cancer therapies and other specialized medications.
• Kinase Inhibitor Research: Serves as a core scaffold for the design and development of novel kinase inhibitors due to its privileged pyrazolopyrimidine structure.
• Chemical Biology & Proteomics: Used as a tool compound or a tagged ligand in biochemical assays to study protein function and signaling pathways.
• Medicinal Chemistry: Provides a versatile template for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Fine Chemical Synthesis: Employed in multi-step organic synthesis to construct complex molecules for academic and industrial research.
• Reference Standard: Supplied as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	7-(3-Amino-Phenyl)-Pyrazolo[1,5-A]Pyrimidine-3-Carboxylic Acid Ethyl Ester Hydrochloride
CAS No.	1185449-65-3
Molecular Formula	C15H15N5O2 • HCl
Molecular Weight	333.77 g/mol (Free base: 297.31 g/mol)
Synonyms	Ethyl 7-(3-aminophenyl)pyrazolo[1,5-a]pyrimidine-3-carboxylate hydrochloride; 7-(3-Aminophenyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid ethyl ester hydrochloride; 1185449-65-3; APPPE-HCl; Pyrazolo[1,5-a]pyrimidine-3-carboxylic acid, 7-(3-aminophenyl)-, ethyl ester, hydrochloride; Ethyl 7-(m-aminophenyl)pyrazolo[1,5-a]pyrimidine-3-carboxylate HCl
EINECS	Contact for details

Quality Control

Our 7-(3-Amino-Phenyl)-Pyrazolo[1,5-A]Pyrimidine-3-Carboxylic Acid Ethyl Ester Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis, to ensure it meets the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability, consistency, and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.