Description

4-Chloro-2-Piperazin-1-Yl-Pyrimidine Hydrochloride is a high-purity pharmaceutical intermediate and building block of significant importance in modern organic synthesis. Its core value lies in its role as a versatile precursor for the development of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitor research. This compound is essential for research and development chemists, process chemists, and manufacturers in the pharmaceutical, biotechnology, and fine chemical industries who require reliable, high-quality building blocks for drug discovery and scale-up.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of kinase inhibitors and other targeted therapeutic agents.
• Drug Discovery & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Chemical Biology Research: Serves as a probe or precursor for studying biological pathways and protein interactions.
• Process Chemistry & Scale-Up: Employed in the development and optimization of scalable synthetic routes for API manufacturing.
• Fine Chemical Synthesis: Utilized for constructing complex heterocyclic compounds in custom synthesis projects.

Basic Information

Product Name	4-Chloro-2-Piperazin-1-Yl-Pyrimidine Hydrochloride
CAS No.	1185316-90-8
Molecular Formula	C8H13ClN4•HCl
Molecular Weight	245.13 g/mol (as hydrochloride salt)
Synonyms	4-Chloro-2-(piperazin-1-yl)pyrimidine hydrochloride; 2-(1-Piperazinyl)-4-chloropyrimidine hydrochloride; 4-Chloro-2-piperazin-1-ylpyrimidine HCl; 4-Chloro-2-(1-piperazinyl)pyrimidine monohydrochloride; 1185316-90-8; 4-Chloro-2-piperazin-1-yl-pyrimidine HCl
EINECS	Contact for details

Quality Control

Our 4-Chloro-2-Piperazin-1-Yl-Pyrimidine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for pharmaceutical R&D and production. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.