Description

Fmoc-α-Methyl-3-Methoxy-Dl-Phenylalanine CAS NO 1185301-96-5 is a protected, non-natural amino acid derivative designed for advanced peptide synthesis. This compound is critical for introducing structural modifications and enhancing the metabolic stability of synthetic peptides. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic peptides, peptidomimetics, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key building block for incorporating a modified phenylalanine residue with an α-methyl group and methoxy substituent into peptide chains.
• Peptidomimetic Drug Discovery: Used to create peptide analogs with improved bioavailability, receptor selectivity, and resistance to enzymatic degradation.
• Medicinal Chemistry Research: Serves as a versatile intermediate in the synthesis of constrained peptides and bioactive compounds for target validation.
• Bioconjugation and Probe Development: The Fmoc protecting group allows for orthogonal deprotection strategies, making it suitable for creating labeled peptides or affinity tags.
• Academic and Industrial R&D: Essential for fundamental studies in peptide structure-activity relationships (SAR) and the development of new synthetic methodologies.

Basic Information

Product Name	Fmoc-α-Methyl-3-Methoxy-Dl-Phenylalanine
CAS No.	1185301-96-5
Molecular Formula	C26H25NO5
Molecular Weight	431.48 g/mol
Synonyms	Fmoc-α-Me-3-MeO-DL-Phe-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-methoxy-α-methyl-DL-phenylalanine; Fmoc-(α-Me)-3-OMe-DL-Phe; 2-[(9H-Fluoren-9-ylmethoxy)carbonyl]amino-2-methyl-3-(3-methoxyphenyl)propanoic acid; Fmoc-3-Methoxy-α-methyl-DL-phenylalanine; N-Fmoc-3-methoxy-α-methyl-DL-phenylalanine; DL-Fmoc-α-methyl-3-methoxyphenylalanine
EINECS	Contact for details

Quality Control

Our Fmoc-α-Methyl-3-Methoxy-Dl-Phenylalanine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and chiral analysis to verify the DL-mixture. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or cGMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.