Description

5-Piperidin-3-Yl-7-Trifluoromethyl-Imidazo[1,2-A]-Pyrimidine Dihydrochloride is a high-purity, advanced pharmaceutical intermediate with significant utility in modern drug discovery and development. This compound is valued for its complex heterocyclic structure, which serves as a critical building block for synthesizing novel bioactive molecules targeting a range of therapeutic areas. It is primarily sought after by research institutions, contract research organizations (CROs), and pharmaceutical companies engaged in medicinal chemistry and preclinical studies.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel small-molecule drug candidates, particularly in oncology and central nervous system (CNS) research.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies to optimize potency, selectivity, and pharmacokinetic properties.
• Kinase Inhibitor Development: Serves as a building block for potential kinase inhibitors due to its imidazopyrimidine core, relevant for targeted cancer therapies.
• Chemical Biology Probes: Utilized in the development of chemical probes to study specific biological pathways and protein functions.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis and scale-up projects under cGMP conditions.
• Academic Research: Employed in university and institutional labs for exploratory synthetic chemistry and pharmacological screening.

Basic Information

Product Name	5-Piperidin-3-Yl-7-Trifluoromethyl-Imidazo[1,2-A]-Pyrimidine Dihydrochloride
CAS No.	1185299-45-9
Molecular Formula	C14H17Cl2F3N4
Molecular Weight	369.21 g/mol
Synonyms	5-(Piperidin-3-yl)-7-(trifluoromethyl)imidazo[1,2-a]pyrimidine dihydrochloride; 7-Trifluoromethyl-5-piperidin-3-yl-imidazo[1,2-a]pyrimidine dihydrochloride; Imidazo[1,2-a]pyrimidine, 5-(3-piperidinyl)-7-(trifluoromethyl)-, dihydrochloride; 1185299-45-9; 5-Piperidin-3-yl-7-trifluoromethylimidazo[1,2-a]pyrimidine HCl; 5-(3-Piperidyl)-7-(trifluoromethyl)imidazo[1,2-a]pyrimidine dihydrochloride
EINECS	Contact for details

Quality Control

Our 5-Piperidin-3-Yl-7-Trifluoromethyl-Imidazo[1,2-A]-Pyrimidine Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production can align with cGMP guidelines for advanced pharmaceutical intermediates, supporting regulatory filings for investigational new drugs (IND).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity	≤ 1.0%
Total Impurities	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.