Description

Fmoc-2-Amino-5-Fluorobenzoic Acid is a high-purity, protected amino acid derivative essential for solid-phase peptide synthesis (SPPS). This compound serves as a critical building block for introducing the 2-amino-5-fluorobenzoic acid moiety into peptide chains, enabling the creation of complex molecules for research and development. It is primarily utilized by pharmaceutical researchers, biotech companies, and CROs engaged in the development of novel therapeutic peptides, peptidomimetics, and chemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid, it is a fundamental reagent for the automated, stepwise construction of custom peptides.
• Pharmaceutical Intermediate: Used in the research and development of active pharmaceutical ingredients (APIs) and drug candidates containing fluorinated aromatic amino acid structures.
• Chemical Biology & Proteomics: Employed in the synthesis of labeled peptides, activity-based probes, and substrates for enzyme studies.
• Material Science: Can be incorporated into specialty polymers and advanced materials where fluorinated aromatic components are required.
• Academic & Industrial R&D: Serves as a key starting material for medicinal chemistry programs and structure-activity relationship (SAR) studies.

Basic Information

Product Name	Fmoc-2-Amino-5-Fluorobenzoic Acid
CAS No.	1185296-60-9
Molecular Formula	C₂₂H₁₆FNO₄
Molecular Weight	377.36 g/mol
Synonyms	Fmoc-2-Abz(5-F)-OH; 2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-5-fluorobenzoic acid; N-Fmoc-2-amino-5-fluorobenzoic acid; 5-Fluoro-2-[(9H-fluoren-9-ylmethoxycarbonyl)amino]benzoic acid; Fmoc-5-fluoroanthranilic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-5-fluoroanthranilic acid; 2-(Fmoc-amino)-5-fluorobenzoic acid
EINECS	Contact for details

Quality Control

Our Fmoc-2-Amino-5-Fluorobenzoic Acid is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for sensitive research applications. We provide comprehensive analytical data, including HPLC purity, NMR, and mass spectrometry verification. Certificates of Analysis (COA) are available for every batch upon request, detailing all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.