Description

5-Methyl-Benzo[1,2,5]Thiadiazole-4-Sulfonylchloride Hydrochloride is a high-purity, advanced pharmaceutical intermediate and chemical building block. This compound is valued for its role as a key sulfonylation reagent in the synthesis of complex molecules, particularly in medicinal chemistry. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of drug candidates, particularly those containing the benzo[1,2,5]thiadiazole scaffold, which is associated with various biological activities.
• Sulfonamide Synthesis: Serves as a versatile reagent for introducing the sulfonamide functional group into target molecules, a common motif in many active pharmaceutical ingredients (APIs).
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides where the thiadiazole moiety can contribute to biological efficacy.
• Material Science: Employed in the research and development of organic electronic materials, dyes, and pigments due to its electron-accepting properties.
• Chemical Biology & Proteomics: Can be used as a reactive handle for labeling or modifying biomolecules in probe development and biochemical studies.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for use in client-specific synthesis projects.

Basic Information

Item	Details
Product Name	5-Methyl-Benzo[1,2,5]Thiadiazole-4-Sulfonylchloride Hydrochloride
CAS No.	1185293-68-8
Molecular Formula	C7H6ClN2O2S2 • HCl
Molecular Weight	285.13 g/mol (Free base: 248.72 g/mol)
Synonyms	5-Methyl-2,1,3-benzothiadiazole-4-sulfonyl chloride hydrochloride; 4-Methyl-2,1,3-benzothiadiazole-5-sulfonyl chloride hydrochloride; 5-Methylbenzo[c][1,2,5]thiadiazole-4-sulfonyl chloride hydrochloride; 5-Methyl-2,1,3-benzothiadiazole-4-sulfonchloride hydrochloride; 4-Sulfonylchloride-5-methyl-benzo[1,2,5]thiadiazole hydrochloride
EINECS	Contact for details

Quality Control

Our 5-Methyl-Benzo[1,2,5]Thiadiazole-4-Sulfonylchloride Hydrochloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development. Production adheres to cGMP (current Good Manufacturing Practice) guidelines where applicable. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.