Description

n-(2,4-Difluorophenyl)Glycine tert-Butyl Ester CAS NO 1179163-46-2 is a high-purity, protected amino acid derivative featuring a difluorophenyl moiety. This compound is a critical pharmaceutical intermediate used in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in medicinal chemistry research and development. It is primarily utilized by pharmaceutical manufacturers and contract research organizations (CROs) for the development of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug molecules, particularly those targeting central nervous system (CNS) disorders and other therapeutic areas.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new chemical entities with improved efficacy and pharmacokinetic profiles.
• Peptidomimetic Synthesis: Serves as a protected glycine derivative for constructing peptide analogs and mimetics with enhanced metabolic stability.
• API Development: Integral in the multi-step synthesis of Active Pharmaceutical Ingredients (APIs) requiring fluorinated aromatic amino acid components.
• Chemical Biology Probes: Employed in the creation of specialized probes and ligands for studying biological targets and pathways.

Basic Information

Product Name	n-(2,4-Difluorophenyl)Glycine tert-Butyl Ester
CAS No.	1179163-46-2
Molecular Formula	C12H15F2NO2
Molecular Weight	243.25 g/mol
Synonyms	2-[(2,4-Difluorophenyl)amino]acetic acid 1,1-dimethylethyl ester; tert-Butyl N-(2,4-difluorophenyl)glycinate; Glycine, N-(2,4-difluorophenyl)-, 1,1-dimethylethyl ester; (2,4-Difluorophenylamino)-acetic acid tert-butyl ester; N-(2,4-Difluorophenyl)glycine tert-butyl ester; tert-Butyl 2-((2,4-difluorophenyl)amino)acetate
EINECS	Contact for details

Quality Control

Our n-(2,4-Difluorophenyl)Glycine tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for pharmaceutical R&D and manufacturing. Certificates of Analysis (COA) with detailed chromatographic data (HPLC/GC) are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The compound may be moisture-sensitive; keep the container tightly sealed under an inert atmosphere if specified.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.