Description

n-(2,2-Difluoroethyl)-4-Fluoroaniline is a specialized fluorinated aniline derivative, a key building block in advanced organic synthesis. Its value lies in its unique difluoroethyl and fluoroaniline moieties, which are critical for modulating the physicochemical and biological properties of target molecules. This high-purity intermediate is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel active pharmaceutical ingredients (APIs), especially in oncology, CNS, and antiviral research where fluorine substitution is strategic.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, leveraging the fluorine atoms to enhance metabolic stability and bioavailability.
• Material Science Precursor: Serves as a monomer or functionalization agent in the creation of specialty polymers, liquid crystals, and advanced organic electronic materials.
• Fluorinated Ligand Synthesis: Employed in organometallic chemistry and catalysis to create sophisticated ligands for transition metal complexes.
• Chemical Biology Probe Development: Utilized as a scaffold for creating fluorescent tags, PET (Positron Emission Tomography) tracer components, and other molecular probes.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-value fluorinated intermediates.

Basic Information

Product Name	n-(2,2-Difluoroethyl)-4-Fluoroaniline
CAS No.	1178500-33-8
Molecular Formula	C8H8F3N
Molecular Weight	175.15 g/mol
Synonyms	4-Fluoro-N-(2,2-difluoroethyl)aniline; 1-(2,2-Difluoroethylamino)-4-fluorobenzene; N-(2,2-Difluoroethyl)-4-fluoro-benzenamine; 4-Fluoro-N-(2,2-difluoroethyl)benzenamine; Benzenamine, 4-fluoro-N-(2,2-difluoroethyl)-; 2,2-Difluoro-N-(4-fluorophenyl)ethanamine
EINECS	Contact for details

Quality Control

Our n-(2,2-Difluoroethyl)-4-Fluoroaniline is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with agreed specifications. Our commitment to cGMP principles and ISO-aligned processes guarantees a reliable supply of this high-value intermediate for critical R&D and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Due to its sensitivity to oxidation, it is recommended to store under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Standard Grade)
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.