Description

4-(5-Ethyl-1,2,4-Oxadiazol-3-Yl)-2-Piperazin-1-Ylpyrimidine Dihydrochloride is a high-purity, non-nucleoside chemical building block of significant interest in advanced pharmaceutical research and development. Its core value lies in its role as a key synthetic intermediate for creating novel therapeutic agents, particularly in the fields of oncology and central nervous system (CNS) disorders. This compound is primarily needed by R&D laboratories, contract research organizations (CROs), and pharmaceutical companies engaged in the synthesis and screening of new molecular entities. Its defined structure and high purity are critical for ensuring reproducible results in complex multi-step syntheses.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of novel drug candidates targeting specific biological pathways.
• Medicinal Chemistry Research: Used extensively in structure-activity relationship (SAR) studies to optimize the potency and selectivity of lead compounds.
• Kinase Inhibitor Development: Acts as a core scaffold for the design and development of potential kinase inhibitors for cancer therapy.
• CNS Drug Discovery: Employed in research programs aimed at discovering new treatments for neurological and psychiatric conditions.
• Biochemical Tool Compound: Utilized in vitro and in vivo to probe and validate new biological targets and mechanisms of action.
• Custom Synthesis & Scale-Up: Supplied for custom synthesis projects, from milligram-scale discovery to gram/kilogram-scale development.

Basic Information

Product Name	4-(5-Ethyl-1,2,4-Oxadiazol-3-Yl)-2-Piperazin-1-Ylpyrimidine Dihydrochloride
CAS No.	1177092-99-7
Molecular Formula	C₁₂H₁₈Cl₂N₆O
Molecular Weight	333.22 g/mol
Synonyms	2-Piperazin-1-yl-4-(5-ethyl-1,2,4-oxadiazol-3-yl)pyrimidine dihydrochloride; 4-(5-Ethyl-1,2,4-oxadiazol-3-yl)-2-(piperazin-1-yl)pyrimidine dihydrochloride; 4-(5-Ethyl-[1,2,4]oxadiazol-3-yl)-2-piperazin-1-yl-pyrimidine dihydrochloride; UNII-9J2I5K5A4T; 9J2I5K5A4T; 1177092-99-7 (Parent); 4-(5-Ethyl-1,2,4-oxadiazol-3-yl)-2-(1-piperazinyl)pyrimidine dihydrochloride
EINECS	Contact for details

Quality Control

Every batch of 4-(5-Ethyl-1,2,4-Oxadiazol-3-Yl)-2-Piperazin-1-Ylpyrimidine Dihydrochloride is manufactured and tested under a strict quality management system. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency that meet the exacting standards of pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment to guarantee full traceability and compliance with your project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.