Description

Fmoc-(S)-2-Methoxy-Phenylglycine is a protected, non-proteinogenic amino acid derivative essential for solid-phase peptide synthesis (SPPS). This chiral building block is critical for introducing the unique (S)-2-methoxyphenylglycine moiety into peptide sequences, enabling the creation of complex molecules with specific biological activities. It is primarily utilized by pharmaceutical researchers, peptide manufacturers, and biotechnology companies developing novel therapeutic peptides and peptidomimetics.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid, it is a fundamental building block for the automated synthesis of custom peptides.
• Pharmaceutical Research: Used in the discovery and development of novel peptide-based drugs, including enzyme inhibitors and receptor agonists/antagonists.
• Peptidomimetic Design: Incorporates the methoxy-substituted phenylglycine scaffold to enhance metabolic stability, bioavailability, and binding affinity of peptide leads.
• Chemical Biology Probes: Serves as a key component in synthesizing labeled or modified peptides for studying protein-protein interactions and cellular pathways.
• Antibiotic Development: Potential use in constructing complex peptide antibiotics where non-standard amino acids are required for activity.

Basic Information

Product Name	Fmoc-(S)-2-Methoxy-Phenylglycine
CAS No.	1176648-58-0
Molecular Formula	C₂₃H₂₁NO₅
Molecular Weight	391.42 g/mol
Synonyms	Fmoc-(S)-α-(2-Methoxyphenyl)glycine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-2-methoxy-L-phenylglycine; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2-(2-methoxyphenyl)acetic acid; Fmoc-2-MeO-Phg-OH; Fmoc-L-2-Methoxyphenylglycine; N-Fmoc-2-methoxy-L-phenylglycine; Fmoc-2-Methoxy-L-α-phenylglycine
EINECS	Contact for details

Quality Control

Our Fmoc-(S)-2-Methoxy-Phenylglycine is manufactured under strict quality systems to ensure high purity and consistency for sensitive research and production applications. Each batch is analyzed to confirm identity, chiral purity, and chemical purity, with comprehensive Certificates of Analysis (COA) provided. We adhere to cGMP principles where applicable to support pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.