Description

5,8-Dihydro-6H-Pyrido[3,4-D]Pyrimidine-7-Carboxylic Acid tert-Butyl Ester is a high-purity pharmaceutical intermediate and building block of significant importance in modern organic synthesis. This compound matters because it serves as a critical precursor in the development of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitor research. Pharmaceutical R&D departments and fine chemical manufacturers need this material for constructing complex heterocyclic scaffolds. Its defined structure and purity are essential for ensuring the efficacy and safety of downstream drug candidates.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of kinase inhibitors and other targeted therapeutics.
• Organic Synthesis Research: Used in academic and industrial R&D for constructing novel pyrido[3,4-d]pyrimidine derivatives.
• Chemical Biology Probes: Serves as a core structure for developing tool compounds to study biological pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of clinical trial materials and niche APIs.
• Library Synthesis for Drug Discovery: Employed in high-throughput and combinatorial chemistry to generate diverse compound libraries for screening.

Basic Information

Product Name	5,8-Dihydro-6H-Pyrido[3,4-D]Pyrimidine-7-Carboxylic Acid tert-Butyl Ester
CAS No.	1174007-81-8
Molecular Formula	C13H17N3O2
Molecular Weight	247.29 g/mol
Synonyms	tert-Butyl 5,8-dihydro-6H-pyrido[3,4-d]pyrimidine-7-carboxylate; 6H-Pyrido[3,4-d]pyrimidine-7-carboxylic acid, 5,8-dihydro-, 1,1-dimethylethyl ester; 5,8-Dihydro-6H-pyrido[3,4-d]pyrimidine-7-carboxylic acid 1,1-dimethylethyl ester; Pyrido[3,4-d]pyrimidine tert-butyl ester intermediate; CAS 1174007-81-8
EINECS	Contact for details

Quality Control

Our 5,8-Dihydro-6H-Pyrido[3,4-D]Pyrimidine-7-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing purity, impurities, and full analytical data are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.