Description

Cbz-3-Chloro-D-Phenylalanine is a protected, non-natural amino acid derivative featuring a carboxybenzyl (Cbz) protecting group and a chloro substituent on the aromatic ring. This chiral building block is essential for the synthesis of complex peptides and peptidomimetics, where it introduces specific steric, electronic, and conformational properties. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug discovery, particularly for developing protease inhibitors, receptor ligands, and other bioactive compounds.

Application

• Pharmaceutical Intermediates: A key chiral synthon in the research and development of novel active pharmaceutical ingredients (APIs), especially for metabolic and neurological disorders.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate a chlorinated D-phenylalanine residue, influencing peptide stability and bioactivity.
• Protease Inhibitor Development: Serves as a core structural component in the design of selective inhibitors for various proteolytic enzymes.
• Chemical Biology Research: Employed as a molecular probe to study enzyme-substrate interactions, protein folding, and structure-activity relationships (SAR).
• Asymmetric Synthesis: Acts as a valuable chiral pool starting material or auxiliary for the preparation of enantiomerically pure compounds.
• Material Science: Potential use in the synthesis of specialized polymers and functional materials with tailored properties.

Basic Information

Product Name	Cbz-3-Chloro-D-Phenylalanine
CAS No.	1169765-66-5
Molecular Formula	C17H16ClNO4
Molecular Weight	333.77 g/mol
Synonyms	N-[(Benzyloxy)carbonyl]-3-chloro-D-phenylalanine; (R)-2-((((Benzyloxy)carbonyl)amino)-3-(3-chlorophenyl)propanoic acid; Z-3-Chloro-D-Phenylalanine; N-Cbz-3-Chloro-D-Phenylalanine; Nα-Carbobenzoxy-3-chloro-D-phenylalanine; 3-Chloro-D-Phenylalanine, N-Cbz- protected; (R)-2-(Benzyloxycarbonylamino)-3-(3-chlorophenyl)propionic Acid
EINECS	Contact for details

Quality Control

Our Cbz-3-Chloro-D-Phenylalanine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for research and pharmaceutical applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.