Description

Cyclobutanecarboxylic Acid, 3-Hydroxy-3-(Trifluoromethyl)- is a high-value, multifunctional organic building block characterized by its cyclobutane core and trifluoromethyl-substituted tertiary alcohol moiety. This compound is essential for advanced synthetic chemistry, offering a unique steric and electronic profile that enables the construction of complex molecular architectures. It is primarily sought after by R&D and process development teams in the pharmaceutical, agrochemical, and advanced materials sectors for applications in medicinal chemistry and specialty chemical synthesis.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in protease inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and pesticides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of monomers and polymers with tailored properties for high-performance materials.
• Fluorine Chemistry Building Block: Provides a source of the valuable CF3 group for introducing fluorine into target molecules to modulate lipophilicity, bioavailability, and stability.
• Academic and Industrial R&D: A versatile reagent for methodological development and exploration of new chemical spaces in organic synthesis.

Basic Information

Product Name	Cyclobutanecarboxylic Acid, 3-Hydroxy-3-(Trifluoromethyl)-
CAS No.	1163729-49-4
Molecular Formula	C6H7F3O3
Molecular Weight	184.11 g/mol
Synonyms	3-Hydroxy-3-(trifluoromethyl)cyclobutanecarboxylic acid; 3-(Trifluoromethyl)-3-hydroxycyclobutanecarboxylic acid; 3-Hydroxy-3-trifluoromethylcyclobutanecarboxylic acid; 3-(Trifluoromethyl)cyclobutane-1-carboxylic acid, 3-hydroxy-; 1-Carboxy-3-hydroxy-3-(trifluoromethyl)cyclobutane
EINECS	Contact for details

Quality Control

Our production of Cyclobutanecarboxylic Acid, 3-Hydroxy-3-(Trifluoromethyl)- adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with each shipment, confirming compliance with customer specifications and supporting regulatory filings for cGMP and ISO 9001 environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and fluorides. The container must be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.